Literature DB >> 5339840

Kinetics of the thermal inactivation of type E Clostridium botulinum toxin.

J J Licciardello, C A Ribich, J T Nickerson, S A Goldblith.   

Abstract

Rate of inactivation curves for the "free" toxin, prototoxin, or activated toxin in crude filtrates of Clostridium botulinum type E were nonlinear, consisting of a fast inactivating rate followed by a slow inactivating rate. Thermodynamic parameters were calculated over a temperature range of 125 to 145 F (51.7 to 62.8 C) for the two different inactivation rates. Energy of activation was low at the lower temperature and high at the higher temperature. The thermal requirement for inactivating similar concentrations of the "free" toxin, prototoxin, or activated toxin was considered to be the same.

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Year:  1967        PMID： 5339840      PMCID： PMC546903          DOI： 10.1128/am.15.2.344-349.1967

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  7 in total

1.  Activation phenomenon of Clostridium botulinum type E toxin.

Authors:  J GERWING; C E DOLMAN; D A ARNOTT
Journal:  J Bacteriol       Date:  1962-08       Impact factor: 3.490

2.  Thermal inactivation of animal viruses.

Authors:  C WOESE
Journal:  Ann N Y Acad Sci       Date:  1960-01-13       Impact factor: 5.691

3.  Temperature effects on botulinum A toxin.

Authors:  T E CARTWRIGHT; M A LAUFFER
Journal:  Proc Soc Exp Biol Med       Date:  1958-06

4.  Activation of Clostridium botulinum type E toxin by trypsin.

Authors:  J T DUFF; G G WRIGHT; A YARINSKY
Journal:  J Bacteriol       Date:  1956-10       Impact factor: 3.490

5.  COMPARATIVE GEL FILTRATION OF TOXIN PRECURSOR AND TRYPSIN-ACTIVATED TOXIN OF CLOSTRIDIUM BOTULINUM TYPE E.

Authors:  G SAKAGUCHI; S SAKAGUCHI; N IMAI
Journal:  J Bacteriol       Date:  1964-02       Impact factor: 3.490

6.  PURIFICATION AND MOLECULAR WEIGHT DETERMINATION OF CLOSTRIDIUM BOTULINUM TYPE E TOXIN.

Authors:  J GERWING; C E DOLMAN; M E REICHMANN; H S BAINS
Journal:  J Bacteriol       Date:  1964-07       Impact factor: 3.490

7.  Thermal inactivation of type E botulinum toxin.

Authors:  J J Licciardello; J T Nickerson; C A Ribich; S A Goldblith
Journal:  Appl Microbiol       Date:  1967-03
  7 in total
  2 in total

1.  The case of botulinum toxin in milk: experimental data.

Authors:  Oliver G Weingart; Tanja Schreiber; Conny Mascher; Diana Pauly; Martin B Dorner; Thomas F H Berger; Charlotte Egger; Frank Gessler; Martin J Loessner; Marc-Andre Avondet; Brigitte G Dorner
Journal:  Appl Environ Microbiol       Date:  2010-04-02       Impact factor: 4.792

2.  Effect of frozen storage time on heat inactivation of Clostridium botulinum type E toxin.

Authors:  M G Yao; C B Denny; C W Bohrer
Journal:  Appl Microbiol       Date:  1973-03
  2 in total

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