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Literature DB >> 13898102

Activation phenomenon of Clostridium botulinum type E toxin.

Abstract

Gerwing, Julia (The University of British Columbia, Vancouver, Canada), Claude E. Dolman, and David A. Arnott. Activation phenomenon of Clostridium botulinum type E toxin. J. Bacteriol. 84:302-306. 1962-Highly purified preparations of both nonactivated and trypsin-activated type E botulinus toxins have been analyzed in an ultracentrifuge. Untreated botulinus type E toxin was found to have a sedimentation constant (S(20,w)) of 5.6 Svedberg units, whereas trypsin-activated toxins would not form a boundary under identical conditions. These and other considerations indicate that the mechanism of tryptic activation involves a fragmentation process whereby more toxic sites become exposed.

Entities: Disease Species

Keywords: CLOSTRIDIUM BOTULINUM; TOXINS AND ANTITOXINS

Mesh：

Substances：

Year: 1962 PMID： 13898102 PMCID： PMC277861 DOI： 10.1128/jb.84.2.302-306.1962

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

9 in total

1. Studies on toxin production of Clostridium botulinum type E. III. Characterization of toxin precursor.

Authors: G SAKAGUCHI; S SAKAGUCHI
Journal: J Bacteriol Date: 1959-07 Impact factor: 3.490

2. Purification and activation of Clostridium botulinum type E toxin.

Authors: J GERWING; C E DOLMAN; D A ARNOTT
Journal: J Bacteriol Date: 1961-05 Impact factor: 3.490

3. Fish eggs as a cause of human botulism. Two outbreaks in British Columbia due to types E and B botulinus toxins.

Authors: C E DOLMAN; M TOMSICH; C C CAMPBELL; W B LAING
Journal: J Infect Dis Date: 1960 Jan-Feb Impact factor: 5.226

4. Physiology of toxin production by Clostridium botulinum types A and B. IV. Activation of the toxin.

Authors: P F BONVENTRE; L L KEMPE
Journal: J Bacteriol Date: 1960-01 Impact factor: 3.490

5. Recent observations on type E botulism.

Authors: C E DOLMAN
Journal: Can J Public Health Date: 1957-05

6. Activation of Clostridium botulinum type E toxin by trypsin.

Authors: J T DUFF; G G WRIGHT; A YARINSKY
Journal: J Bacteriol Date: 1956-10 Impact factor: 3.490

7. Studies on the toxin production of Clostridium botulinum type E. II. The mode of action of the contaminant organisms to promote toxin production of type E organisms.

Authors: G SAKAGUCHI; Y TOHYAMA
Journal: Jpn J Med Sci Biol Date: 1955-06

8. Studies on immunity to toxins of Clostridium botulinum. VII. Purification and detoxification of trypsin-activated type E toxin.

Authors: M A FIOCK; A YARINSKY; J T DUFF
Journal: J Bacteriol Date: 1961-07 Impact factor: 3.490

9. Studies on the toxin production of Clostridium botulinum type E. I. A strain of genus Clostridium having the action to promote type E botulinal toxin production in a mixed culture.

Authors: G SAKAGUCHI; Y TOHYAMA
Journal: Jpn J Med Sci Biol Date: 1955-06

9 in total

5 in total

Activation phenomenon of Clostridium botulinum type E toxin.

1. Studies on toxin production of Clostridium botulinum type E. III. Characterization of toxin precursor.

2. Purification and activation of Clostridium botulinum type E toxin.

3. Fish eggs as a cause of human botulism. Two outbreaks in British Columbia due to types E and B botulinus toxins.

4. Physiology of toxin production by Clostridium botulinum types A and B. IV. Activation of the toxin.

5. Recent observations on type E botulism.

6. Activation of Clostridium botulinum type E toxin by trypsin.

7. Studies on the toxin production of Clostridium botulinum type E. II. The mode of action of the contaminant organisms to promote toxin production of type E organisms.

8. Studies on immunity to toxins of Clostridium botulinum. VII. Purification and detoxification of trypsin-activated type E toxin.

9. Studies on the toxin production of Clostridium botulinum type E. I. A strain of genus Clostridium having the action to promote type E botulinal toxin production in a mixed culture.

1. Kinetics of the thermal inactivation of type E Clostridium botulinum toxin.

2. Effect of nutrients on physiological properties of Clostridium botulinum type E.

3. COMPARATIVE GEL FILTRATION OF TOXIN PRECURSOR AND TRYPSIN-ACTIVATED TOXIN OF CLOSTRIDIUM BOTULINUM TYPE E.

4. MECHANISM OF TRYPTIC ACTIVATION OF CLOSTRIDIUM BOTULINUM TYPE E TOXIN.

5. PURIFICATION AND MOLECULAR WEIGHT DETERMINATION OF CLOSTRIDIUM BOTULINUM TYPE E TOXIN.