Literature DB >> 5289379

Inhibition of the DNA polymerase of Rauscher leukemia virus by single-stranded polyribonucleotides.

F W Tuominen, F T Kenney.   

Abstract

The DNA polymerase of Rauscher murine leukemia virus is strongly and specifically inhibited by nontemplate, single-stranded polyribonucleotides with either the resident viral RNA, native calf-thymus DNA, or poly[d(A-T)] as templates. These inhibitory homopolymers are apparently bound to the template site of the polymerase, since they interact competitively with the template. The strength of the inhibition depends on the particular homopolymer used: poly(U) > poly(G) >> poly(A) > poly(C). The K(i) for poly(U) was 0.08 mug/ml, which represents an apparent affinity six times greater than that observed for viral RNA. No such inhibition was observed with a highly purified DNA polymerase from mouse embryos or the Escherichia coli enzyme.

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Year:  1971        PMID： 5289379      PMCID： PMC389384          DOI： 10.1073/pnas.68.9.2198

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  RNA Directed DNA synthesis: Identification in L5178Y mouse leukemic cells and distribution of the polymerase in a synchronized L5178Y cell population.

Authors:  H B. Bosmann
Journal:  FEBS Lett       Date:  1971-02-19       Impact factor: 4.124

2.  Properties of a soluble DNA polymerase isolated from Rous sarcoma virus.

Authors:  P Duesberg; K V Helm; E Canaani
Journal:  Proc Natl Acad Sci U S A       Date:  1971-04       Impact factor: 11.205

3.  RNA-dependent DNA polymerase in virions of RNA tumour viruses.

Authors:  D Baltimore
Journal:  Nature       Date:  1970-06-27       Impact factor: 49.962

4.  Characterization of the products of DNA-directed DNA polymerases in oncogenic RNA viruses.

Authors:  S Spiegelman; A Burny; M R Das; J Keydar; J Schlom; M Travnicek; K Watson
Journal:  Nature       Date:  1970-08-08       Impact factor: 49.962

5.  RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Authors:  H M Temin; S Mizutani
Journal:  Nature       Date:  1970-06-27       Impact factor: 49.962

6.  RNA as a template with E. coli DNA polymerase.

Authors:  L F Cavalieri; E Carroll
Journal:  Biochem Biophys Res Commun       Date:  1970-11-25       Impact factor: 3.575

7.  Studies with DNA-cellulose chromatography. I. DNA-binding proteins from Escherichia coli.

Authors:  B M Alberts; F J Amodio; M Jenkins; E D Gutmann; F L Ferris
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1968

8.  Nucleic acid and proteins isolated from the Rauscher mouse leukemia virus (MLV).

Authors:  P H Duesberg; W S Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  1966-01       Impact factor: 11.205

9.  RNA-dependent DNA polymerase: presence in normal human cells.

Authors:  P E Penner; L H Cohen; L A Loeb
Journal:  Biochem Biophys Res Commun       Date:  1971-03-19       Impact factor: 3.575

10.  RNA dependent DNA polymerase activity in mammalian cells.

Authors:  E M Scolnick; S A Aaronson; G J Todaro; W P Parks
Journal:  Nature       Date:  1971-01-29       Impact factor: 49.962
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  16 in total

1.  Affinity chromatography of viral DNA polymerases on pyran-sepharose.

Authors:  J G Chirikjian; L Rye; T S Papas
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205

2.  Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1.

Authors:  T J Bardos; R F Schinazi; K H Ling; A R Heider
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

3.  Specific effect of zinc ions on DNA polymerase activity of avian myeloblastosis virus.

Authors:  P R Palan; M L Eidinoff
Journal:  Mol Cell Biochem       Date:  1978-11-01       Impact factor: 3.396

4.  Effects of polyadenylic acids on functions of murine RNA tumor viruses.

Authors:  R W Tennant; J G Farrelly; J N Ihle; B C Pal; F T Kenney; A Brown
Journal:  J Virol       Date:  1973-12       Impact factor: 5.103

5.  Effects of poly(2'-O-methyladenylic acid) on susceptibility and autogenous immunity to RNA tumor virus oncogenesis in vivo.

Authors:  R W Tennant; M G Hanna; J G Farrelly
Journal:  Proc Natl Acad Sci U S A       Date:  1974-08       Impact factor: 11.205

6.  [Effects of single and double-stranded polynucleotides on nucleic acid synthesis of human leukocytes].

Authors:  H Rainer; P Höcker; B Schweiger; K Moser
Journal:  Klin Wochenschr       Date:  1972-09-15

7.  Reverse transcriptase: a monitor for perturbation effects of spin labels covalently bound to nucleic acids.

Authors:  P E Warwick; A Hakam; A M Bobst
Journal:  Nucleic Acids Res       Date:  1978-07       Impact factor: 16.971

8.  Stimulation of Sendai virion transcriptase by polyanions.

Authors:  H O Stone; D W Kingsbury
Journal:  J Virol       Date:  1973-02       Impact factor: 5.103

9.  Inhibition of RNA-dependent DNA polymerase of avian myeloblastosis virus by pyran copolymer.

Authors:  T S Papas; T W Pry; M A Chirigos
Journal:  Proc Natl Acad Sci U S A       Date:  1974-02       Impact factor: 11.205

10.  Effect of chemically modified 70S RNA from avian myeloblastosis virus (AMV) upon the activity of AMV DNA polymerase.

Authors:  T S Papas; J G Chirikjian; T W Pry; J G Massicot; R D Irwin; M A Chirigos
Journal:  J Virol       Date:  1974-11       Impact factor: 5.103
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