Literature DB >> 527973

Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages.

A T Natarajan, M Meyers.   

Abstract

X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied. At all stages of cell cycles-namely G0, G1, and G2, more aberrations were induced in AT cells than in normal cells. In addition, AT cells were sensitive to induction of chromosomal aberrations by tritium beta rays from incorporated radioactive thymidine. Possible reasons for the increased sensitivity of AT cells for induction of chromosomal aberrations by ionizing radiations are discussed.

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Year:  1979        PMID： 527973     DOI： 10.1007/BF00284606

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

1.  Chromosome breakage and mitotic inhibition induced by tritiated thymidine in root meristems of Vicia faba.

Authors:  A T NATARAJAN
Journal:  Exp Cell Res       Date:  1961-01       Impact factor: 3.905

2.  Defective excision repair of gamma-ray-damaged DNA in human (ataxia telangiectasia) fibroblasts.

Authors:  M C Paterson; B P Smith; P H Lohman; A K Anderson; L Fishman
Journal:  Nature       Date:  1976-04-01       Impact factor: 49.962

3.  Is chromatid-type damage in ataxia telangiectasia after irradiation at G0 a consequence of defective repair?

Authors:  A M Taylor; J A Metcalfe; J M Oxford; D G Harnden
Journal:  Nature       Date:  1976-04-01       Impact factor: 49.962

4.  Micrococcus luteus UV-endonuclease-sensitive sites and sister-chromatid exchanges in Chinese hamster ovary cells.

Authors:  R J Reynolds; A T Natarajan; P H Lohman
Journal:  Mutat Res       Date:  1979-10       Impact factor: 2.433

5.  The formation and recovery of two-break chromosome rearrangements from irradiated spermatozoa of Drosophila melanogaster.

Authors:  B Leigh
Journal:  Mutat Res       Date:  1978-01       Impact factor: 2.433

6.  The timing of the restitution of chromosome breaks induced by X-rays in the mature sperm of Drosophila melanogaster.

Authors:  R H Maddern; B Leigh
Journal:  Mutat Res       Date:  1976-12       Impact factor: 2.433

7.  Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations.

Authors:  A M Taylor
Journal:  Mutat Res       Date:  1978-06       Impact factor: 2.433

8.  Excision of gamma-ray induced thymine lesions by preparations from ataxia telangiectasia fibroblasts.

Authors:  J F Remsen; P A Cerutti
Journal:  Mutat Res       Date:  1977-04       Impact factor: 2.433

9.  DNA strained breakage repair in ataxia telangiectasia fibroblast-like cells.

Authors:  R A Vincent; R B Sheridan; P C Huang
Journal:  Mutat Res       Date:  1975-12       Impact factor: 2.433

10.  Use of the 5-bromodeoxyuridine-labelling technique for exploring mechanisms involved in the formation of chromosomal aberrations.

Authors:  A T Natarajan; B A Kihlman; G Obe
Journal:  Mutat Res       Date:  1980-12       Impact factor: 2.433
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  15 in total

1.  Heterogeneity in the clastogenic response to X-rays in lymphocytes from ataxia-telangiectasia heterozygotes and controls.

Authors:  J K Wiencke; D W Wara; J B Little; K T Kelsey
Journal:  Cancer Causes Control       Date:  1992-05       Impact factor: 2.506

2.  Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22.

Authors:  C M McConville; C J Formstone; D Hernandez; J Thick; A M Taylor
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

3.  In vivo chromosomal instability in ataxia-telangiectasia homozygotes and heterozygotes.

Authors:  M P Rosin; H D Ochs
Journal:  Hum Genet       Date:  1986-12       Impact factor: 4.132

4.  Effect of caffeine in G2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells.

Authors:  K Hansson; A T Natarajan; B A Kihlman
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

5.  Chromatid damage after G2 phase x-irradiation of cells from cancer-prone individuals implicates deficiency in DNA repair.

Authors:  R Parshad; K K Sanford; G M Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

Review 6.  Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect.

Authors:  P J McKinnon
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

7.  The effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro.

Authors:  A T Natarajan; G Obe; F N Dulout
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

8.  Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer.

Authors:  W Jongmans; G W Verhaegh; N G Jaspers; M Oshimura; E J Stanbridge; P H Lohman; M Z Zdzienicka
Journal:  Am J Hum Genet       Date:  1995-02       Impact factor: 11.025

Review 9.  Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective.

Authors:  J P Murnane
Journal:  Cancer Metastasis Rev       Date:  1995-03       Impact factor: 9.264

10.  Complementation of a DNA repair deficiency in six human tumor cell lines by chromosome 11.

Authors:  R Parshad; F M Price; M Oshimura; J C Barrett; H Satoh; B E Weissman; E J Stanbridge; K K Sanford
Journal:  Hum Genet       Date:  1992-03       Impact factor: 4.132
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