Literature DB >> 6469243

Effect of caffeine in G2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells.

K Hansson, A T Natarajan, B A Kihlman.   

Abstract

The effect of post-treatments with caffeine in G2 on the frequency of X-ray-induced chromatid aberrations was studied in normal and ataxia telangiectasia (A-T) fibroblast and lymphoblastoid cells. Caffeine was found to potentiate the X-ray-induced aberration yield in both normal fibroblast and lymphoblastoid cells. An enhancement was also observed in A-T lymphoblastoid cells, whereas the X-ray-induced aberration frequency in A-T fibroblasts was unaffected by the presence of caffeine. The influence of caffeine on the radiation-induced mitotic inhibition was investigated in normal and A-T fibroblasts; in both types of cell less inhibition was obtained in the presence of caffeine.

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Year:  1984        PMID： 6469243     DOI： 10.1007/bf00291363

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  28 in total

1.  Cytogenetic investigations in families with ataxia-telangiectasia.

Authors:  M M Cohen; M Shaham; J Dagan; E Shmueli; G Kohn
Journal:  Cytogenet Cell Genet       Date:  1975

2.  Chromosomal radiation sensitivity in ataxia telangiectasia long-term lymphoblastoid cell lines.

Authors:  L G Littlefield; S P Colyer; E E Joiner; R J DuFrain; E Frome; M M Cohen
Journal:  Cytogenet Cell Genet       Date:  1981

3.  Effect of caffeine on DNA synthesis in irradiated and unirradiated mammalian cells.

Authors:  R B Painter
Journal:  J Mol Biol       Date:  1980-11-05       Impact factor: 5.469

4.  Ataxia telangiectasia: chromosomal stability in continuous lymphoblastoid cell lines.

Authors:  M M Cohen; M Sagi; Z Ben-Zur; T Schaap; R Voss; G Kohn; H Ben-Bassat
Journal:  Cytogenet Cell Genet       Date:  1979

5.  The effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro.

Authors:  A T Natarajan; G Obe; F N Dulout
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

6.  DNA of HeLa cells during caffeine-promoted recovery from X-ray induced G2 arrest.

Authors:  R Bases; F Mendez; D Liebeskind; F Elequin; S Neubort
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1980-04

7.  Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages.

Authors:  A T Natarajan; M Meyers
Journal:  Hum Genet       Date:  1979-11-01       Impact factor: 4.132

8.  Effects of caffeine on radiation-induced phenomena associated with cell-cycle traverse of mammalian cells.

Authors:  R A Walters; L R Gurley; R A Tobey
Journal:  Biophys J       Date:  1974-02       Impact factor: 4.033

9.  The rate of DNA synthesis in normal human and ataxia telangiectasia cells after exposure to X-irradiation.

Authors:  J de Wit; N G Jaspers; D Bootsma
Journal:  Mutat Res       Date:  1981-01       Impact factor: 2.433

10.  Ataxia telangiectasia: an anomaly in DNA replication after irradiation.

Authors:  M D Ford; M F Lavin
Journal:  Nucleic Acids Res       Date:  1981-03-25       Impact factor: 16.971
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  3 in total

Review 1.  Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect.

Authors:  P J McKinnon
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

2.  Differential expression of the ICF (immunodeficiency, centromeric heterochromatin, facial anomalies) mutation in lymphocytes and fibroblasts.

Authors:  P Maraschio; R Tupler; E Dainotti; M Piantanida; G Cazzola; L Tiepolo
Journal:  J Med Genet       Date:  1989-07       Impact factor: 6.318

3.  The effect of caffeine on fragile X expression.

Authors:  M A Abruzzo; D Pettay; M Mayer; P A Jacobs
Journal:  Hum Genet       Date:  1986-05       Impact factor: 4.132
  3 in total

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