Literature DB >> 6446519

The effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro.

A T Natarajan, G Obe, F N Dulout.   

Abstract

The potentiating effect of caffeine on X-ray-induced chromosomal aberrations in human blood lymphocytes has been investigated, with special reference to cell cycle stages (G0 and G2). Both quantitative and qualitative differences in the yield of chromosomal aberrations were detected in caffeine-posttreated cells, depending on the cell stage irradiated. The studies on caffeine potentiating effects on X-irradiated G0 lymphocytes from normal adults, newborns, Down syndrome patients, and an ataxia telangiectasia patient pointed to interindividual variations in the response to caffeine potentiation among normal probands and a very profound effect in ataxia cells.

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Year:  1980        PMID： 6446519     DOI： 10.1007/bf00278969

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  6 in total

1.  The human leukocyte test system. V. DNA synthesis and mitoses in PHA-stimulated 3-day cultures.

Authors:  G Obe; B Beek; G Dudin
Journal:  Humangenetik       Date:  1975-08-25

2.  Defective excision repair of gamma-ray-damaged DNA in human (ataxia telangiectasia) fibroblasts.

Authors:  M C Paterson; B P Smith; P H Lohman; A K Anderson; L Fishman
Journal:  Nature       Date:  1976-04-01       Impact factor: 49.962

3.  Repair of gamma-ray and neutron-induced lesions in germinating barley seeds.

Authors:  G Ahnström; A T Natarajan
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1971

4.  Molecular mechanisms involved in the production of chromosomal aberrations. II. Utilization of Neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle.

Authors:  A T Natarajan; G Obe; A A van Zeeland; F Palitti; M Meijers; E A Verdegaal-Immerzeel
Journal:  Mutat Res       Date:  1980-02       Impact factor: 2.433

5.  Caffeine-inhibited DNA repair in 7-bromomethylbenz (a)-anthracene-treated Chinease hamster cells: formation of breaks in parental DNA and inhibition of ligation of nascent DNA as a mechanism for enhancement of lethality and chromosome damage.

Authors:  F Friedlos; J J Roberts
Journal:  Mutat Res       Date:  1978-05       Impact factor: 2.433

6.  Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages.

Authors:  A T Natarajan; M Meyers
Journal:  Hum Genet       Date:  1979-11-01       Impact factor: 4.132
  6 in total
  5 in total

1.  A system for mutation measurement in mammalian cells: application to gamma-irradiation.

Authors:  T T Puck; R Johnson; S Rasumussen
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

2.  Effect of caffeine in G2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells.

Authors:  K Hansson; A T Natarajan; B A Kihlman
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

Review 3.  Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective.

Authors:  J P Murnane
Journal:  Cancer Metastasis Rev       Date:  1995-03       Impact factor: 9.264

4.  Association between Genomic Instability and Evolutionary Chromosomal Rearrangements in Neotropical Primates.

Authors:  Fiona Puntieri; Nancy B Andrioli; Mariela Nieves
Journal:  Genome Biol Evol       Date:  2018-07-01       Impact factor: 3.416

5.  Melatonin-Caffeine Combination Modulates Gamma Radiation-induced Sperm Malformations in C57BL/6 Male Mice at Sublethal Dose of Gamma Radiation.

Authors:  Ritu Kushwaha; Dhruv K Nishad; Aseem Bhatnagar; Roop Krishen Khar
Journal:  J Pharm Bioallied Sci       Date:  2021-05-25
  5 in total

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