Literature DB >> 672922

Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations.

A M Taylor.   

Abstract

It is suggested here that the unusually high level of radiation-induced chromosome and chromatid-type aberrations in cells from patients with ataxia telangiectasia, compared with normals, is due to a significantly increased fraction of unrepaired double and single strand breaks. A hypothesis is proposed to explain how unrepaired and misrepaired DNA single or double strand breaks might be the basic lesion leading to the typical chromosome aberrations seen following X-irradiation of both normal or AT cells.

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Year:  1978        PMID： 672922     DOI： 10.1016/0027-5107(78)90045-3

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  22 in total

Review 1.  Genetic and biochemical studies with ataxia telangiectasia. A review.

Authors:  P C Huang; R B Sheridan
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

Review 2.  Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells.

Authors:  M Frankenberg-Schwager
Journal:  Radiat Environ Biophys       Date:  1990       Impact factor: 1.925

3.  Patients with an inherited syndrome characterized by immunodeficiency, microcephaly, and chromosomal instability: genetic relationship to ataxia telangiectasia.

Authors:  N G Jaspers; R D Taalman; C Baan
Journal:  Am J Hum Genet       Date:  1988-01       Impact factor: 11.025

Review 4.  Cell cycle checkpoints and DNA repair preserve the stability of the human genome.

Authors:  W K Kaufmann
Journal:  Cancer Metastasis Rev       Date:  1995-03       Impact factor: 9.264

5.  The response of ataxia telangiectasia cells to bleomycin.

Authors:  A R Lehmann; S Stevens
Journal:  Nucleic Acids Res       Date:  1979       Impact factor: 16.971

6.  Studies on the radiosensitivity of cells from patients with basal cell naevus syndrome.

Authors:  T Featherstone; A M Taylor; D G Harnden
Journal:  Am J Hum Genet       Date:  1983-01       Impact factor: 11.025

7.  Chromatid damage after G2 phase x-irradiation of cells from cancer-prone individuals implicates deficiency in DNA repair.

Authors:  R Parshad; K K Sanford; G M Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

8.  Spontaneous and mutagen induced sister chromatid exchange in multiple sclerosis.

Authors:  M S Newton; C M Steel; H J Evans; B Pentland
Journal:  J Med Genet       Date:  1983-10       Impact factor: 6.318

Review 9.  Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect.

Authors:  P J McKinnon
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

10.  Chromosomal radiosensitivity during the G2 cell-cycle period of skin fibroblasts from individuals with familial cancer.

Authors:  R Parshad; K K Sanford; G M Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205
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