Literature DB >> 5274448

A genetic marker in the variable region of light chains of mouse immunoglobulins.

G M Edelman, P D Gottlieb.   

Abstract

A genetic variation was observed upon autoradiographic comparison of tryptic peptide maps of (14)C-labeled normal light chains from 17 different inbred strains of mice. The difference was found in strains AKR/J, C58/J, and RF/J. Chemical analyses showed that the differences were in a region of the amino acid sequence in the neighborhood of half-cystine I of the variable region of the light chain. Breeding experiments showed that the difference segregated in a classical Mendelian fashion.

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Year:  1970        PMID： 5274448      PMCID： PMC283336          DOI： 10.1073/pnas.67.3.1192

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  16 in total

1.  Two structurally distinct classes of kappa-chains in human immunoglobulins.

Authors:  H D Niall; P Edman
Journal:  Nature       Date:  1967-10-21       Impact factor: 49.962

2.  Linked groups of residues in immunoglobulin k chains.

Authors:  C Milstein
Journal:  Nature       Date:  1967-10-28       Impact factor: 49.962

3.  Mechanism of antibody synthesis: size differences between mouse kappa chains.

Authors:  W R Gray; W J Dreyer; L Hood
Journal:  Science       Date:  1967-01-27       Impact factor: 47.728

4.  Non-allelic nature of the basic sequences of normal immunoglobulin K chains.

Authors:  C Milstein; C P Milstein; A Feinstein
Journal:  Nature       Date:  1969-01-11       Impact factor: 49.962

Review 5.  The antibody problem.

Authors:  G M Edelman; W E Gall
Journal:  Annu Rev Biochem       Date:  1969       Impact factor: 23.643

6.  The covalent structure of a human gamma G-immunoglobulin. I. Isolation and characterization of the whole molecule, the polypeptide chains, and the tryptic fragments.

Authors:  G M Edelman; W E Gall; M J Waxdal; W H Konigsberg
Journal:  Biochemistry       Date:  1968-05       Impact factor: 3.162

7.  The covalent structure of a human gamma G-immunoglobulin. V. Partial amino acid sequence of the light chain.

Authors:  B A Cummingham; P D Gottlieb; W H Konigsberg; G M Edelman
Journal:  Biochemistry       Date:  1968-05       Impact factor: 3.162

8.  Subgroups of amino acid sequences in the variable regions of immunoglobulin heavy chains.

Authors:  B A Cunningham; M N Pflumm; U Rutishauser; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1969-11       Impact factor: 11.205

9.  Allelic antigenic factor Inv(a) of the light chains of human immunoglobulins: chemical basis.

Authors:  C Baglioni; L Alescio Zonta; D Cioli; A Carbonara
Journal:  Science       Date:  1966-06-10       Impact factor: 47.728

10.  Evidence for multiple gene control of a single polypeptide chain: the heavy chain of rabbit immunoglobulin.

Authors:  M E Koshland; J J Davis; N J Fujita
Journal:  Proc Natl Acad Sci U S A       Date:  1969-08       Impact factor: 11.205
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  31 in total

1.  Structural differences in a single gene encoding the V kappa Ser group of light chains explain the existence of two mouse light-chain genetic markers.

Authors:  R T Boyd; M M Goldrick; P D Gottlieb
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

2.  Polymorphism in V kappa 10 genes encoding L chains of antibodies bearing the Ars-A and A48 cross-reactive idiotypes.

Authors:  S O Kim; I Sanz; C Williams; J D Capra; P D Gottlieb
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846

3.  Structural and evolutionary comparisons of four alleles of the mouse Igk-J locus which encodes immunoglobulin kappa light chain joining (J kappa) segments.

Authors:  P D Ponath; R T Boyd; D M Hillis; P D Gottlieb
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

4.  Identity of the V kappa 10-Ars-A gene segments of the A/J and BALB/c strains.

Authors:  K Meek; I Sanz; G Rathbun; A Nisonoff; J D Capra
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

5.  Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype.

Authors:  J A Laskin; A Gray; A Nisonoff; N R Klinman; P D Gottlieb
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

6.  Unusual fragments in the subunit structure of concanavalin A.

Authors:  J L Wang; B A Cunningham; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

7.  Heavy-chain variable regions in normal and pathological immunolobulins.

Authors:  A C Wang; H H Fudenberg; J R Pink
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

8.  The Ly-3 antigens on mouse thymocytes: immune precipitation and molecular weight characterization.

Authors:  P J Durda; P D Gottlieb
Journal:  J Exp Med       Date:  1976-08-01       Impact factor: 14.307

9.  A genetic marker in the variable region of rabbit immunoglobulin heavy chain.

Authors:  L R Mole
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

10.  BALB/c antiarsonate idiotypes: gene complementation necessary for expression.

Authors:  A R Brown; P D Gottlieb
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846
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