Literature DB >> 4162931

Mechanism of antibody synthesis: size differences between mouse kappa chains.

W R Gray, W J Dreyer, L Hood.   

Abstract

Structural analysis of immunoglobulin light chains has been carried out in an attempt to elucidate the genetic mechanisms involved in antibody synthesis. Analysis of two mouse kappa-chain proteins is almost complete. The differences are localized in one-half of the molecules, and do not reflect the operation of any one mutational mechanism. The peculiar character of the differences is discussed with reference to various theories of antibody formation. The finding that the two proteins differ in size is incompatible with certain proposed theories.

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Year:  1967        PMID： 4162931     DOI： 10.1126/science.155.3761.465

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  39 in total

1.  Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

Authors:  E E Max; J G Seidman; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

2.  Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions.

Authors:  D J McKean; M Bell; M Potter
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

Review 3.  [Development of the immune system (author's transl)].

Authors:  J A Schwarz
Journal:  Klin Wochenschr       Date:  1974-09-15

4.  Two types of lambda polypeptide chains in human immunoglobulins based on an amino acid substitution at position 190.

Authors:  E Appella; D Ein
Journal:  Proc Natl Acad Sci U S A       Date:  1967-05       Impact factor: 11.205

5.  Enzymatic synthesis of DNA complementary to purified 14S messenger RNA of immunoglobulin light chain.

Authors:  H Digglemann; C H Faust; B Mach
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

6.  Sequence variation among heavy chains from inulin-binding myeloma proteins.

Authors:  M Vrana; S Rudikoff; M Potter
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

7.  Amino acid sequence similarities in two human anti gamma globulin antibodies.

Authors:  J D Capra; H G Kunkel
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205

8.  Purification and properties of biologically active messenger RNA for a myeloma light chain.

Authors:  D Swan; H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

9.  Partial amino acid sequences of kappa-chains of rat immunoglobulins: genetic and evolutionary implications.

Authors:  A C Wang; H H Fudenberg; H Bazin
Journal:  Biochem Genet       Date:  1976-04       Impact factor: 1.890

10.  Amino acid-sequence variability at the N-terminal extra piece of mouse immunoglobulin light-chain precursors of the same and different subgroups.

Authors:  Y Burstein; I Schechter
Journal:  Biochem J       Date:  1976-07-01       Impact factor: 3.857
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