Literature DB >> 52290

The effect of Trimepranol on thrombocyte function and histamin release in the rat.

R Nosal, Z Menyhardtová.   

Abstract

Trimepranol a beta adrenergic blocking drug released serotonin from rat isolated and plasma-rich thrombocytes in vitro. The release was time- and dose-dependent. With the same concentrations this drug inhibited the histamine release from isolated rat mast cells. Aggregation of isolated or plasma-rich thrombocytes induced by ADP was inhibited by Trimepranol. The inhibition was dose, time dependent and reversed by calcium ions.

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Year:  1975        PMID： 52290     DOI： 10.1007/bf02027151

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  22 in total

1.  Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors:  G V BORN
Journal:  Nature       Date:  1962-06-09       Impact factor: 49.962

2.  [Not Available].

Authors:  R FEISSLY; H LUDIN
Journal:  Rev Hematol       Date:  1949

3.  Platelet behaviour and drugs used in cardiovascular disease.

Authors:  J R Hampton; M J Harrison; A J Honour; J R Mitchell
Journal:  Cardiovasc Res       Date:  1967-04       Impact factor: 10.787

4.  Membrane stabilization and cardiac effects of d,1-propranolol, d-propranolol and chlorpromazine.

Authors:  A Langslet
Journal:  Eur J Pharmacol       Date:  1970       Impact factor: 4.432

5.  Inhibition of the release of histamine from rat mast cells: the effect of cold and adrenergic drugs on release of histamine by compound 48-80 and antigen.

Authors:  A R Johnson; N C Moran
Journal:  J Pharmacol Exp Ther       Date:  1970-12       Impact factor: 4.030

6.  Quantitative correlation between degranulation and histamine release following exposure of rat mast cells to compound 48-80 in vitro.

Authors:  R Nósal; S A Slorach; B Uvnäs
Journal:  Acta Physiol Scand       Date:  1970-10

7.  Measurement of hydrophobicity, surface activity, local anaesthesia, and myocardial conduction velocity as quantitative parameters of the non-specific membrane affinity of nine -adrenergic blocking agents.

Authors:  D Hellenbrecht; B Lemmer; G Wiethold; H Grobecker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

8.  Plasma serotonin levels in stored human blood.

Authors:  H W Strauss; R B Smith; P Polimeni; A C Schenker; V J Schenker; J H Stuckey
Journal:  Angiology       Date:  1967-09       Impact factor: 3.619

9.  Effects of adrenaline on human blood platelets.

Authors:  D C Mills; G C Roberts
Journal:  J Physiol       Date:  1967-11       Impact factor: 5.182

10.  Membrane effects of beta-adrenergic blocking agents: investigations with the fluorescence probe 1-anilino-8-naphthalene sulfonate (ANS) and antihemolytic activities.

Authors:  G Wiethold; D Hellenbrecht; B Lemmer; D Palm
Journal:  Biochem Pharmacol       Date:  1973-06-15       Impact factor: 5.858
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  5 in total

1.  The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiestease on histamine release from isolated mast cells.

Authors:  R Nosál; Z Menyhardtová
Journal:  Agents Actions       Date:  1977-07

2.  Beta-adrenoceptor blocking drugs and calcium transport in isolated rat mast cells.

Authors:  K Drábiková; J Pecivová; R Nosál
Journal:  Agents Actions       Date:  1989-04

3.  Quantitative correlation between histamine and 35S release from isolated rat mast cells due to the beta-adrenergic blocking drug Kö 1124.

Authors:  R Nosál; J Pecivová; K Drábiková
Journal:  Agents Actions       Date:  1981-07

4.  On the interaction of beta-adrenoceptor-blocking drugs with isolated mast cells.

Authors:  R Nosál; J Pecivová; K Drábiková
Journal:  Agents Actions       Date:  1985-09

5.  Evidence for intracellular histamine liberation in isolated rat mast cells.

Authors:  R Nosál; J Pecivova; K Drábiková
Journal:  Agents Actions       Date:  1982-12
  5 in total

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