Literature DB >> 514814

Novobiocin; an inhibitor of the repair of UV-induced but not X-ray-induced damage in mammalian cells.

A Collins, R Johnson.   

Abstract

In addition to inhibiting replicative DNA synthesis in HeLa cells, novobiocin has a severe effect on the cellular response to UV irradiation, reducing the number of breaks made in pre-existing DNA by the excision repair process. The inhibition of UV repair by novobiocin is reflected in enhanced UV-killing of these cells. Rejoining of DNA after X irradiation is not impaired by novobiocin. The recognition and removal of UV damage may require unwinding of the DNA by gyrase, which--in bacteria--is the target for novobiocin.

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Year:  1979        PMID： 514814      PMCID： PMC342304          DOI： 10.1093/nar/7.5.1311

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  16 in total

1.  Antagonists of DNA gyrase inhibit repair and recombination of UV-irradiated phage lambda.

Authors:  J B Hays; S Boehmer
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

Review 2.  Proteins that affect DNA conformation.

Authors:  J J Champoux
Journal:  Annu Rev Biochem       Date:  1978       Impact factor: 23.643

3.  DNA damage in ultraviolet-irradiated HeLa and CHO-Kl cells examined by alkaline lysis and hydroxyapatite chromatography.

Authors:  A R Collins
Journal:  Biochim Biophys Acta       Date:  1977-10-18

4.  DNA damage in synchronized HeLa cells irradiated with ultraviolet.

Authors:  C S Downes; A R Collins; R T Johnson
Journal:  Biophys J       Date:  1979-01       Impact factor: 4.033

5.  Reversal of the changes in DNA and chromosome structure which follow the inhibition of UV-induced repair in human cells.

Authors:  R T Johnson; A R Collins
Journal:  Biochem Biophys Res Commun       Date:  1978-01-30       Impact factor: 3.575

6.  The influence of inhibitors on dimer removal and repair of single-strand breaks in normal and bromodeoxyuridine substituted DNA of HeLa cells.

Authors:  J J Cornelis
Journal:  Biochim Biophys Acta       Date:  1978-11-21

7.  Single-strand breaks in DNA during repair of UV-induced damage in normal human and xeroderma pigmentosum cells as determined by alkaline DNA unwinding and hydroxylapatite chromatography: effects of hydroxyurea, 5-fluorodeoxyuridine and 1-beta-D-arabinofuranosylcytosine on the kinetics of repair.

Authors:  K Erixon; G Ahnström
Journal:  Mutat Res       Date:  1979-02       Impact factor: 2.433

8.  Repair and survival after UV in quiescent and proliferating Microtus agrestis cells: different rates of incision and different dependence on DNA precursor supply.

Authors:  A R Collins; R T Johnson
Journal:  J Cell Physiol       Date:  1979-04       Impact factor: 6.384

9.  Escherichia coli DNA synthesis in vitro: insensitivity of ATP-dependent DNA repair to inhibition by novobiocin.

Authors:  P K Schneck; W L Staudenbauer
Journal:  Nucleic Acids Res       Date:  1977-06       Impact factor: 16.971

10.  The effect of cytosine arabinoside on the frequency of single-strand breaks in DNA of mammalian cells following irradiation or chemical treatment.

Authors:  E A Hiss; R J Preston
Journal:  Biochim Biophys Acta       Date:  1977-09-06
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  18 in total

1.  The effect of novobiocin on yeast topoisomerase type II.

Authors:  M J Pocklington; J R Jenkins; E Orr
Journal:  Mol Gen Genet       Date:  1990-01

2.  Repair of UV-induced lesions in Xenopus laevis oocytes.

Authors:  R J Legerski; J E Penkala; C A Peterson; D A Wright
Journal:  Mol Cell Biol       Date:  1987-12       Impact factor: 4.272

3.  Inhibitors of repair DNA synthesis.

Authors:  A R Collins; S Squires; R T Johnson
Journal:  Nucleic Acids Res       Date:  1982-02-25       Impact factor: 16.971

4.  Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice.

Authors:  J G Spivack; D R O'Boyle; N W Fraser
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

5.  The effect of preincubation of HeLa cell nuclei with ATP on the degradation of mononucleosomal DNA by micrococcal nuclease.

Authors:  M Pentz; R Vatev; D A Goldthwait
Journal:  Nucleic Acids Res       Date:  1986-07-11       Impact factor: 16.971

6.  The effects of inhibitors of topoisomerase II and quinacrine on ultraviolet-light-induced DNA incision in normal and xeroderma pigmentosum fibroblasts.

Authors:  H W Thielmann; O Popanda; L Edler
Journal:  J Cancer Res Clin Oncol       Date:  1991       Impact factor: 4.553

7.  Inhibition of recovery from potentially lethal damage by chemicals in Chinese hamster V79 A cells.

Authors:  A Kumar; J Kiefer; E Schneider; N E Crompton
Journal:  Radiat Environ Biophys       Date:  1985       Impact factor: 1.925

8.  Stimulation of DNA repair synthesis of rat thymocytes by novobiocin and nalidixic acid in vitro without detectable DNA damage.

Authors:  K Tempel; A Spath
Journal:  Arch Toxicol       Date:  1987-06       Impact factor: 5.153

9.  Studies on the inhibition of repair of ultraviolet- and methyl methanesulfonate-induced damage in the DNA of human fibroblasts by novobiocin.

Authors:  R D Snyder; B Van Houten; J D Regan
Journal:  Nucleic Acids Res       Date:  1982-10-11       Impact factor: 16.971

10.  Effects of novobiocin on adenovirus DNA synthesis and encapsidation.

Authors:  J C D'Halluin; M Milleville; P Boulanger
Journal:  Nucleic Acids Res       Date:  1980-04-11       Impact factor: 16.971
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