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Literature DB >> 514808

A nuclear precursor to human gamma-globin messenger RNA.

Abstract

RNA isolated from human foetal liver at an erythroid stage of development was transferred from methyl mercury hydroxide agarose gels to diazobenzyloxymethyl paper. A 16S RNA species containing gamma-globin mRNA sequences was identified by hybridisation to 32P-labelled human gamma-globin cDNA recombinant plasmid pHgamma GI. This RNA is found only in the cell nucleus and is polyadenylated. Human globin gene transcription is thus analagous to that in mouse: interventing sequences are transcribed and processed from the pre-mRNA in the nucleus after polyadenylation.

Entities: Chemical Gene Mutation Species

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Year: 1979 PMID： 514808 PMCID： PMC342290 DOI： 10.1093/nar/7.5.1121

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

31 in total

1. Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.

Authors: S M Tilghman; D C Tiemeier; J G Seidman; B M Peterlin; M Sullivan; J V Maizel; P Leder
Journal: Proc Natl Acad Sci U S A Date: 1978-02 Impact factor: 11.205

2. A characterization of globin mRNA sequences in the nucleus of duck immature red blood cells.

Authors: R K Strair; A I Skoultchi; D A Shafritz
Journal: Cell Date: 1977-09 Impact factor: 41.582

3. The precursor of mouse beta-globin messenger RNA contains two intervening RNA sequences.

Authors: A J Kinniburgh; J E Mertz; J Ross
Journal: Cell Date: 1978-07 Impact factor: 41.582

4. Precursors of alpha and beta globin messenger RNAs.

Authors: J Ross; D A Knecht
Journal: J Mol Biol Date: 1978-02-15 Impact factor: 5.469

5. Structure of the human fetal globin gene locus.

Authors: P F Little; R A Flavell; J M Kooter; G Annison; R Williamson
Journal: Nature Date: 1979-03-15 Impact factor: 49.962

6. Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing.

Authors: O Smithies; A E Blechl; K Denniston-Thompson; N Newell; J E Richards; J L Slightom; P W Tucker; F R Blattner
Journal: Science Date: 1978-12-22 Impact factor: 47.728

7. A physical map of the DNA regions flanking the rabbit beta-globin gene.

Authors: A J Jeffreys; R A Flavell
Journal: Cell Date: 1977-10 Impact factor: 41.582

8. Isolation and partial sequence of recombinant plasmids containing human alpha-, beta- and gamma-globin cDNA fragments.

Authors: P Little; P Curtis; C Coutelle; J Van den Berg; R Dalgleish; S Malcolm; M Courtney; D Westaway; R Williamson
Journal: Nature Date: 1978-06-22 Impact factor: 49.962