Literature DB >> 274720

The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.

S M Tilghman, P J Curtis, D C Tiemeier, P Leder, C Weissmann.   

Abstract

Mouse beta-globin in encoded in a discontinuous structural gene interrupted by a 550-base pair intervening sequence of DNA. Correspondingly, the mature beta-globin mRNA appears to be synthesized via a 15S precursor, the length of which roughly equals the total length of the coding and intervening sequences of the beta-globin gene. Using the electron microscope to visualize hybrid structures formed between this gene and the purified 15S beta-globin mRNA precursor, we show that the intervening sequence is present within the larger precursor molecule. This finding suggests that the precursor mRNA is processed through the removal and rejoining of internal RNA sequences.

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Year:  1978        PMID： 274720      PMCID： PMC411460          DOI： 10.1073/pnas.75.3.1309

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  A precursor of globin messenger RNA.

Authors:  J Ross
Journal:  J Mol Biol       Date:  1976-09-15       Impact factor: 5.469

2.  Organization and expression of early genes of simian virus 40.

Authors:  L V Crawford; C N Cole; A E Smith; E Paucha; P Tegtmeyer; K Rundell; P Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

3.  Globin RNA precursor molecules: biosynthesis and process in erythroid cells.

Authors:  R N Bastos; H Aviv
Journal:  Cell       Date:  1977-07       Impact factor: 41.582

4.  Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences.

Authors:  S M Tilghman; D C Tiemeier; F Polsky; M H Edgell; J G Seidman; A Leder; L W Enquist; B Norman; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

5.  Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.

Authors:  S M Tilghman; D C Tiemeier; J G Seidman; B M Peterlin; M Sullivan; J V Maizel; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

6.  Purification of globin messenger RNA from dimethylsulfoxide-induced Friend cells and detection of a putative globin messenger RNA precursor.

Authors:  P J Curtis; C Weissmann
Journal:  J Mol Biol       Date:  1976-10-05       Impact factor: 5.469

7.  The rabbit beta-globin gene contains a large large insert in the coding sequence.

Authors:  A J Jeffreys; R A Flavell
Journal:  Cell       Date:  1977-12       Impact factor: 41.582

8.  Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.

Authors:  Y Aloni; R Dhar; O Laub; M Horowitz; G Khoury
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

9.  Presence of a putative 15S precursor to beta-globin mRNA but not to alpha-globin mRNA in Friend cells.

Authors:  P J Curtis; N Mantei; J van den Berg; C Weissmann
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

10.  Purification of a putative precursor of globin messenger RNA from mouse nucleated erythroid cells.

Authors:  S P Kwan; T G Wood; J B Lingrel
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205
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  69 in total

1.  Variable and constant regions are separated in the 10-kbase transcription unit coding for immunoglobulin kappa light chains.

Authors:  M Gilmore-Herbert; K Hercules; M Komaromy; R Wall
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

2.  Electron microscopic analysis of transcription: mapping of initiation sites and direction of transcription.

Authors:  C Brack
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

3.  The rat serum albumin gene: analysis of cloned sequences.

Authors:  T D Sargent; J R Wu; J M Sala-Trepat; R B Wallace; A A Reyes; J Bonner
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

Review 4.  Multiple forms of inducible drug-metabolizing enzymes: a reasonable mechanism by which any organism can cope with adversity.

Authors:  D W Nebert
Journal:  Mol Cell Biochem       Date:  1979-09-28       Impact factor: 3.396

5.  Identification of the major polyadenylylated transcription products and the genes active in their synthesis in a rat insulinoma.

Authors:  J R Duguid; D F Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

6.  Maturation of polycistronic pre-mRNA in Trypanosoma brucei: analysis of trans splicing and poly(A) addition at nascent RNA transcripts from the hsp70 locus.

Authors:  J Huang; L H van der Ploeg
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

7.  Localization of pre-messenger RNA at discrete nuclear sites.

Authors:  J Wang; L G Cao; Y L Wang; T Pederson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

Review 8.  Contributions of microbiology to eucaryotic cell biology: new directions for microbiology.

Authors:  R Dulbecco
Journal:  Microbiol Rev       Date:  1979-12

9.  Lengths of transcribed rDNA repeating units in spermatocytes of Drosophila hydei: only genes without an intervening sequence are expressed.

Authors:  K H Glätzer
Journal:  Chromosoma       Date:  1979-11       Impact factor: 4.316

10.  Inserted sequence in the mitochondrial 23S ribosomal RNA gene of the yeast Saccharomyces cerevisiae.

Authors:  G Faye; N Dennebouy; C Kujawa; C Jacq
Journal:  Mol Gen Genet       Date:  1979-01-05
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