Literature DB >> 423971

Structure of the human fetal globin gene locus.

P F Little, R A Flavell, J M Kooter, G Annison, R Williamson.   

Abstract

We have derived a 'map' of restriction enzyme sites in and around the human gamma-globin genes. This has enabled us to show that there are two gamma-globin genes per haploid set, that the genes contain 'introns' within the same regions of DNA as the human beta and delta-globin genes, and that the genes are 3,500 base pairs apart. We conclude that the correct gene organisation of the human beta-like globin locus is GgammaAgammadeltabeta.

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Year:  1979        PMID： 423971     DOI： 10.1038/278227a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  22 in total

1.  Molecular cloning of human epsilon-globin gene.

Authors:  N J Proudfoot; F E Baralle
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

Review 2.  Mapping haemoglobin genes.

Authors:  D J Weatherall
Journal:  Br Med J       Date:  1979-08-11

3.  Structure of the human G gamma-A gamma-delta-beta-globin gene locus.

Authors:  R Bernards; P F Little; G Annison; R Williamson; R A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

4.  Assignment of human beta-, gamma-, and delta-globin genes to the short arm of chromosome 11 by chromosome sorting and DNA restriction enzyme analysis.

Authors:  R V Lebo; A V Carrano; K Burkhart-Schultz; A M Dozy; L C Yu; Y W Kan
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

5.  RNA polymerase III transcriptional units are interspersed among human non-alpha-globin genes.

Authors:  C Duncan; P A Biro; P V Choudary; J T Elder; R R Wang; B G Forget; J K de Riel; S M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

6.  Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia.

Authors:  S H Orkin; B P Alter; C Altay
Journal:  J Clin Invest       Date:  1979-09       Impact factor: 14.808

7.  Restriction endonuclease mapping of the human gamma globin gene loci.

Authors:  D Tuan; P A Biro; J K deRiel; H Lazarus; B G Forget
Journal:  Nucleic Acids Res       Date:  1979-06-11       Impact factor: 16.971

Review 8.  Testis-organizing H-Y antigen as a discrete protein; its MHC restricted recognition and the genomic environment in which H-Y gene operates.

Authors:  S Ohno; J T Epplen; S Sutou
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

9.  A novel type of secondary modification of two CCGG residues in the human gamma delta beta-globin gene locus.

Authors:  L H van der Ploeg; J Groffen; R A Flavell
Journal:  Nucleic Acids Res       Date:  1980-10-24       Impact factor: 16.971

Review 10.  The molecular basis of disorders of human hemoglobin synthesis.

Authors:  F Ramirez; J G Mears; A Bank
Journal:  Mol Cell Biochem       Date:  1980-08-16       Impact factor: 3.396
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