Literature DB >> 725604

Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing.

O Smithies, A E Blechl, K Denniston-Thompson, N Newell, J E Richards, J L Slightom, P W Tucker, F R Blattner.   

Abstract

Two globin-related clones isolated from collections of bacteriophages containing unfractionated Eco RI fragments of human and mouse DNA were characterized. Charon3AHs51.1Hbgamma includes 2.7 kilobase pairs of human DNA containing a large part of a fetal gamma globin chain structural gene; Charon 3AMm30.5 includes 4.7 kilobase pairs of mouse DNA related to alpha globin. The human fetal gamma globin gene has within its coding region two intervening sequences of noncoding DNA, IVS 1 and IVS 2, of approximately 1-0 and 900 base pairs. Sequence IVS 1 is located at the position of one of the two intervening sequences occurring in adult globin genes; IVS 2 is located at the position of the other.

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Year:  1978        PMID： 725604     DOI： 10.1126/science.725604

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

1.  Molecular cloning of human epsilon-globin gene.

Authors:  N J Proudfoot; F E Baralle
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

2.  Restriction endonuclease mapping of the human gamma globin gene loci.

Authors:  D Tuan; P A Biro; J K deRiel; H Lazarus; B G Forget
Journal:  Nucleic Acids Res       Date:  1979-06-11       Impact factor: 16.971

3.  Novel models for RNA splicing that involve a small nuclear RNA.

Authors:  Y Ohshima; M Itoh; N Okada; T Miyata
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

4.  Molecular cloning and partial characterization of unintegrated linear DNA from gibbon ape leukemia virus.

Authors:  M L Scott; K McKereghan; H S Kaplan; K E Fry
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

5.  Cloning and direct examination of a structurally abnormal human beta 0-thalassemia globin gene.

Authors:  S H Orkin; R Kolodner; A Michelson; R Husson
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

Review 6.  Sequence organization of animal nuclear DNA.

Authors:  J Schmidtke; J T Epplen
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

7.  A mechanism for RNA splicing.

Authors:  J Rogers; R Wall
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

8.  Deletions in the alpha-globin gene complex in alpha-thalassemic mice.

Authors:  J B Whitney; J Martinell; R A Popp; L B Russell; W F Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

9.  Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia.

Authors:  Y Shibasaki; T Kawakami; Y Kanazawa; Y Akanuma; F Takaku
Journal:  J Clin Invest       Date:  1985-07       Impact factor: 14.808

Review 10.  The molecular basis of disorders of human hemoglobin synthesis.

Authors:  F Ramirez; J G Mears; A Bank
Journal:  Mol Cell Biochem       Date:  1980-08-16       Impact factor: 3.396
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