Literature DB >> 511179

Urinary pepsinogen isozymes: a highly polymorphic locus in man.

R T Taggart, R C Karn, A D Merritt, P L Yu, P M Conneally.   

Abstract

A genetic analysis of human urinary pepsinogen isozymes is presented. Nine discrete phenotypes were identified in a population survey of 215 unrelated Caucasian individuals. The phenotypes were characterized by differences among the staining intensities of the activated group I pepsinogens, Pg 5, Pg 4, Pg 3, and Pg 2. The genetic studies demonstrated that the codominant expression of four alleles, PgA, PgB, PgC and PgD, at a single genetic locus determined the nine phenotypes identified. Linkage analysis excluded close linkage of the Pg locus with the chromosome 6 markers HLA, GLO1, and Bf.

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Year:  1979        PMID： 511179     DOI： 10.1007/bf00271578

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  14 in total

1.  Pepsinogens: new variant and linkage relationships to chromosome 6 markers.

Authors:  T Gedde-Dahl; L Korsnes; E Thorsby; B Olaisen; A Bratlie; A Siverts
Journal:  Cytogenet Cell Genet       Date:  1978

2.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

3.  Pepsinogen polymorphism frequencies in a Negro population.

Authors:  P L Townes; M R White
Journal:  Am J Hum Genet       Date:  1974-03       Impact factor: 11.025

4.  Pepsinogens: genetic polymorphism in man.

Authors:  I M Samloff; P L Townes
Journal:  Science       Date:  1970-04-03       Impact factor: 47.728

5.  Electrophoretic heterogeneity and relationships of pepsinogens in human urine, serum, and gastric mucosa.

Authors:  I M Samloff; P L Townes
Journal:  Gastroenterology       Date:  1970-04       Impact factor: 22.682

6.  A general model for the genetic analysis of pedigree data.

Authors:  R C Elston; J Stewart
Journal:  Hum Hered       Date:  1971       Impact factor: 0.444

7.  Further data concerning the linkage relationships of loci for urinary pepsinogen and HLA.

Authors:  L R Weitkamp
Journal:  Cytogenet Cell Genet       Date:  1978

8.  4th International Workshop on Human Gene Mapping. Report of the committee on the genetic constitution of chromosome 6.

Authors: 
Journal:  Cytogenet Cell Genet       Date:  1978

9.  Genetic analysis of urinary pepsinogen isozymes.

Authors:  R T Taggart; P L Yu; R C Karn; P M Conneally; A D Merritt
Journal:  Cytogenet Cell Genet       Date:  1978

10.  Duodenal-ulcer disease associated with elevated serum pepsinogen I: an inherited autosomal dominant disorder.

Authors:  J I Rotter; J Q Sones; I M Samloff; C T Richardson; J M Gursky; J H Walsh; D L Rimoin
Journal:  N Engl J Med       Date:  1979-01-11       Impact factor: 91.245
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  13 in total

1.  Newly characterized genetic polymorphism of uropepsinogen group A (PGA) using both isoelectric focusing and immunoblotting.

Authors:  K Kishi; T Yasuda
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

2.  Molecular cloning of a pair of human pepsinogen A genes which differ by a Glu----Lys mutation in the activation peptide.

Authors:  M P Evers; B Zelle; D S Peeper; W H Mager; R J Planta; A W Eriksson; R R Frants
Journal:  Hum Genet       Date:  1987-10       Impact factor: 4.132

3.  Relationships between the human pepsinogen DNA and protein polymorphisms.

Authors:  R T Taggart; I M Samloff; L J Raffel; A Graham; C Cass; G M Petersen; J I Rotter; M H Skolnick; C E Schwartz; G I Bell
Journal:  Am J Hum Genet       Date:  1986-06       Impact factor: 11.025

4.  Discrepancies between gastric mucosal and urinary pepsinogen A patterns and in vitro synthesis and secretion of human pepsinogen.

Authors:  G Pals; B D Westerveld; J Defize; J C Pronk; H Brand; M Flipse; C Verwey; S G Meuwissen; A W Eriksson
Journal:  Dig Dis Sci       Date:  1988-02       Impact factor: 3.199

5.  Variable numbers of pepsinogen genes are located in the centromeric region of human chromosome 11 and determine the high-frequency electrophoretic polymorphism.

Authors:  R T Taggart; T K Mohandas; T B Shows; G I Bell
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

6.  New detection method for uropepsinogen (PGA) using isoelectric focusing and immunoblotting techniques.

Authors:  T Yasuda; Y Ikehara; W Sato; K Kishi
Journal:  Z Rechtsmed       Date:  1987

7.  Genomic structure and evolution of the human pepsinogen A multigene family.

Authors:  B Zelle; M P Evers; P C Groot; J P Bebelman; W H Mager; R J Planta; J C Pronk; S G Meuwissen; M H Hofker; A W Eriksson
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

8.  Genetics of urinary pepsinogen: a new hypothesis.

Authors:  R R Frants; J C Pronk; G Pals; J Defize; B D Westerveld; S G Meuwissen; J Kreuning; A W Eriksson
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

9.  Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.

Authors:  B Zelle; A Geurts van Kessel; J de Wit; P Evers; F Arwert; J C Pronk; W H Mager; R J Planta; A W Eriksson; R R Frants
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

10.  Linkage of a gene controlling urinary pepsinogen with the major histocompatibility complex of the mouse.

Authors:  J M Szymura; J Klein
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846
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