Literature DB >> 3104199

Newly characterized genetic polymorphism of uropepsinogen group A (PGA) using both isoelectric focusing and immunoblotting.

K Kishi, T Yasuda.   

Abstract

Genetic polymorphism of uropepsinogen group A (PGA) was characterized in human urine using a technique involving both polyacrylamide gel isoelectric focusing and immunoblotting with an anti-PGA antibody. PGA was clearly separable into five fractions, termed I to V in order of decreasing anodal mobility. The most slowly migrating fraction V was composed of F (fast) and/or S (slow) band(s). The population frequencies of the three patterns of fraction V (F, FS, and S) and family studies indicated that PGA V is controlled by a pair of alleles, PGA V*F and PGA V*S, at a single autosomal locus, and that both are codominant. The frequencies of the genes are 0.07 for PGA V*F and 0.93 for PGA V*S.

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Year:  1987        PMID： 3104199     DOI： 10.1007/bf00281060

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  7 in total

1.  Proteins of human urine. I. Concentration and analysis by two-dimensional electrophoresis.

Authors:  N G Anderson; N L Anderson; S L Tollaksen
Journal:  Clin Chem       Date:  1979-07       Impact factor: 8.327

2.  Variable numbers of pepsinogen genes are located in the centromeric region of human chromosome 11 and determine the high-frequency electrophoretic polymorphism.

Authors:  R T Taggart; T K Mohandas; T B Shows; G I Bell
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

3.  Pepsinogens: genetic polymorphism in man.

Authors:  I M Samloff; P L Townes
Journal:  Science       Date:  1970-04-03       Impact factor: 47.728

4.  Uropepsinogen in human urine: its protein nature, activation and enzymatic properties of activated enzyme.

Authors:  N Minamiura; K Ito; M Kobayashi; O Kobayashi; T Yamamoto
Journal:  J Biochem       Date:  1984-10       Impact factor: 3.387

5.  Genetics of urinary pepsinogen: a new hypothesis.

Authors:  R R Frants; J C Pronk; G Pals; J Defize; B D Westerveld; S G Meuwissen; J Kreuning; A W Eriksson
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

6.  Genetics of pepsinogen I.

Authors:  L Korsnes; T Gedde-Dahl
Journal:  Ann Hum Genet       Date:  1980-01       Impact factor: 1.670

7.  Urinary pepsinogen isozymes: a highly polymorphic locus in man.

Authors:  R T Taggart; R C Karn; A D Merritt; P L Yu; P M Conneally
Journal:  Hum Genet       Date:  1979-11       Impact factor: 4.132
  7 in total
  5 in total

1.  Human serum deoxyribonuclease I (DNase I) polymorphism: pattern similarities among isozymes from serum, urine, kidney, liver, and pancreas.

Authors:  K Kishi; T Yasuda; Y Ikehara; K Sawazaki; W Sato; R Iida
Journal:  Am J Hum Genet       Date:  1990-07       Impact factor: 11.025

2.  A hereditary double double-banded variation in the vitamin D-binding protein (GC) system analyzed by immunoblotting: duplication of the 1F and 1A2 genes?

Authors:  T Yasuda; Y Ikehara; S Takagi; K Mizuta; K Kishi
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

3.  New detection method for uropepsinogen (PGA) using isoelectric focusing and immunoblotting techniques.

Authors:  T Yasuda; Y Ikehara; W Sato; K Kishi
Journal:  Z Rechtsmed       Date:  1987

4.  Genetic polymorphism of human urine deoxyribonuclease I.

Authors:  K Kishi; T Yasuda; S Awazu; K Mizuta
Journal:  Hum Genet       Date:  1989-02       Impact factor: 4.132

5.  Discovery of a genetic polymorphism of human plasma protein C inhibitor (PCI): genetic survey utilizing isoelectric focusing followed by immunoblotting, immunological and biochemical characterization.

Authors:  T Yasuda; D Nadano; R Iida; Y Tanaka; M Nakanaga; K Kishi
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132
  5 in total

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