| Literature DB >> 510175 |
Abstract
Mice of the C57Bl and C3H strains regained their righting reflex at higher brain ethanol levels than those at which they had lost their righting reflex, indicating that these animals developed acute tolerance. DBA mice did not develop acute tolerance. DBA mice "slept" significantly longer than C57Bl mice, but all mice lost their righting reflex at similar brain ethanol levels. Mice of SS and LS lines also showed no evidence for developing acute tolerance but differed significantly in brain ethanol levels upon loss of righting reflex. Both acute tolerance development and initial brain sensitivity to ethanol seem to determine duration of ethanol "sleep time" in mice.Entities:
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Year: 1979 PMID： 510175 DOI： 10.1016/0376-8716(79)90043-7
Source DB: PubMed Journal: Drug Alcohol Depend ISSN： 0376-8716 Impact factor: 4.492