Literature DB >> 3131793

Characteristics of ethanol tolerance in alcohol drinking (AA) and alcohol avoiding (ANA) rats.

A D Lê1, K Kiianmaa.   

Abstract

The development of tolerance to ethanol was examined in two rat lines selected for high (AA) and low (ANA) ethanol consumption. In the first experiment, the acquisition of tolerance to the motor-impairment, hypothermic and hypnotic effects of ethanol produced by daily treatment with 5 g/kg ethanol for a period of 24 days was examined. Tolerance to these effects of ethanol was observed in the AA rats while marginal or no tolerance was demonstrated in the ANA rats. In the second experiment the development of rapid tolerance to the hypothermic and hypnotic effects of ethanol was examined. The hypothermic and hypnotic responses to IP injection of 3.5 g/kg ethanol were found to be attenuated in the AA but not the ANA rats by a single equivalent ethanol injection given 24 h earlier. These results suggest some relationship between the capacity to develop tolerance and voluntary ethanol intake.

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Year:  1988        PMID： 3131793     DOI： 10.1007/bf00212841

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  19 in total

1.  Rapid development of tolerance to the hypothermic effect of ethanol in mice.

Authors:  J C Crabbe; H Rigter; J Uijlen; C Strijbos
Journal:  J Pharmacol Exp Ther       Date:  1979-01       Impact factor: 4.030

2.  The determination of acetaldehyde in biological samples by head-space gas chromatography.

Authors:  C J Eriksson; H W Sippel; O A Forsander
Journal:  Anal Biochem       Date:  1977-05-15       Impact factor: 3.365

3.  Ethanol preference and behavioral tolerance in mice: biochemical and neurophysiological mechanisms.

Authors:  C W Schneider
Journal:  J Comp Physiol Psychol       Date:  1973-03

4.  Genetic influences on the rate of development of ethanol tolerance and the ethanol physical withdrawal syndrome in mice.

Authors:  S J Grieve; P J Griffiths; J M Littleton
Journal:  Drug Alcohol Depend       Date:  1979 Jan-Mar       Impact factor: 4.492

5.  Initial sensitivity and acute tolerance to ethanol in the P and NP lines of rats.

Authors:  M B Waller; W J McBride; L Lumeng; T K Li
Journal:  Pharmacol Biochem Behav       Date:  1983-10       Impact factor: 3.533

6.  The role of conditional drug responses in tolerance to the hypothermic effects of ethanol.

Authors:  C R Crowell; R E Hinson; S Siegel
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

7.  Conditioned tolerance to the hypothermic effect of ethyl alcohol.

Authors:  A D Lê; C X Poulos; H Cappell
Journal:  Science       Date:  1979-11-30       Impact factor: 47.728

8.  Intoxicating effects of three aliphatic alcohols and barbital on two rat strains genetically selected for their ethanol intake.

Authors:  A Malila
Journal:  Pharmacol Biochem Behav       Date:  1978-02       Impact factor: 3.533

9.  Revitalization of the AA and ANA rat lines: effects on some line characteristics.

Authors:  L Hilakivi; C J Eriksson; M Sarviharju; J D Sinclair
Journal:  Alcohol       Date:  1984 Jan-Feb       Impact factor: 2.405

10.  Interrelationships of alcohol consumption, actions of alcohol, and biochemical traits.

Authors:  V G Erwin; G E McClearn; A R Kuse
Journal:  Pharmacol Biochem Behav       Date:  1980       Impact factor: 3.533
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  23 in total

Review 1.  An experimental approach to understanding the genetic and neurobiological basis of alcoholism.

Authors:  T K Li; L Lumeng; W J McBride; J M Murphy
Journal:  Trans Am Clin Climatol Assoc       Date:  1993

2.  Differential development of acute tolerance to the motor impairment and anticonvulsant effects of ethanol.

Authors:  A D Lê; M Mana; B Quan; H Kalant
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

3.  The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster.

Authors:  Anita V Devineni; Kimberly D McClure; Douglas J Guarnieri; Ammon B Corl; Fred W Wolf; Mark Eddison; Ulrike Heberlein
Journal:  Fly (Austin)       Date:  2011-07-01       Impact factor: 2.160

4.  Initial sensitivity, acute tolerance and alcohol consumption in Fischer 344 and Long Evans rats.

Authors:  J M Khanna; H Kalant; H Sharma; A Chau
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

5.  Role of initial sensitivity and genetic factors in the development of tolerance to ethanol in AT and ANT rats.

Authors:  A D Lê; K Kiianmaa
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

6.  Effects of acute ethanol on beta-endorphin release in the nucleus accumbens of selectively bred lines of alcohol-preferring AA and alcohol-avoiding ANA rats.

Authors:  Minh P Lam; Harri Nurmi; Noora Rouvinen; Kalervo Kiianmaa; Christina Gianoulakis
Journal:  Psychopharmacology (Berl)       Date:  2009-11-26       Impact factor: 4.530

Review 7.  Human and laboratory rodent low response to alcohol: is better consilience possible?

Authors:  John C Crabbe; Richard L Bell; Cindy L Ehlers
Journal:  Addict Biol       Date:  2010-04       Impact factor: 4.280

8.  Differences in the hypothermic response to ethanol in rats selectively bred for oral ethanol preference and nonpreference.

Authors:  R B Stewart; D L Kurtz; M Zweifel; T K Li; J C Froehlich
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

Review 9.  Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

Authors:  Richard L Bell; Helen J K Sable; Giancarlo Colombo; Petri Hyytia; Zachary A Rodd; Lawrence Lumeng
Journal:  Pharmacol Biochem Behav       Date:  2012-07-25       Impact factor: 3.533

10.  Relationship between ethanol's acute locomotor effects and ethanol self-administration in male Long-Evans rats.

Authors:  Ann M Chappell; Jeff L Weiner
Journal:  Alcohol Clin Exp Res       Date:  2008-09-25       Impact factor: 3.455
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