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Literature DB >> 8099788

Selective breeding for alcohol preference and associated responses.

Abstract

Selective breeding for high and low alcohol-drinking preference has produced rat lines useful for studying the nature of excessive alcohol-seeking behavior. Compared with the alcohol-nonpreferring line, the preferring animals exhibit heightened responsivity to the low-dose activating effects of ethanol as well as enhanced capacity for developing tolerance to the aversive, behaviorally impairing effects of ethanol. The preferring animals exhibit lower brain serotonin and dopamine neurotransmitter activity as well as differences in other neurotransmitter neuromodulator systems, compared with the alcohol-nonpreferring animals.

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Year: 1993 PMID： 8099788 DOI： 10.1007/bf01067421

Source DB: PubMed Journal: Behav Genet ISSN： 0001-8244 Impact factor: 2.805

45 in total

Review 1. Molecular associations of alcohol-seeking behavior in rat lines selectively bred for high and low voluntary ethanol drinking.

Authors: T K Li; L Lumeng; D P Doolittle; L G Carr
Journal: Alcohol Alcohol Suppl Date: 1991

2. Serotonin and dopamine systems regulating alcohol intake.

Authors: W J McBride; J M Murphy; G J Gatto; A D Levy; L Lumeng; T K Li
Journal: Alcohol Alcohol Suppl Date: 1991

3. Effect of spontaneous ingestion of ethanol on brain dopamine metabolism.

Authors: F Fadda; E Mosca; G Colombo; G L Gessa
Journal: Life Sci Date: 1989 Impact factor: 5.037

4. Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats.

Authors: P E Penn; W J McBride; L Lumeng; T M Gaff; T K Li
Journal: Pharmacol Biochem Behav Date: 1978-04 Impact factor: 3.533

5. Initial sensitivity and acute tolerance to ethanol in the P and NP lines of rats.

Authors: M B Waller; W J McBride; L Lumeng; T K Li
Journal: Pharmacol Biochem Behav Date: 1983-10 Impact factor: 3.533

6. Correlative analysis of ethanol-related phenotypes in rat inbred strains.

Authors: K Spuhler; R A Deitrich
Journal: Alcohol Clin Exp Res Date: 1984 Sep-Oct Impact factor: 3.455

Review 7. Modulation of ethanol intake by serotonin uptake inhibitors.

Authors: C A Naranjo; E M Sellers; M O Lawrin
Journal: J Clin Psychiatry Date: 1986-04 Impact factor: 4.384

8. Increased number of GABAergic terminals in the nucleus accumbens is associated with alcohol preference in rats.

Authors: B H Hwang; L Lumeng; J Y Wu; T K Li
Journal: Alcohol Clin Exp Res Date: 1990-08 Impact factor: 3.455

9. Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats.

Authors: J M Murphy; M B Waller; G J Gatto; W J McBride; L Lumeng; T K Li
Journal: Alcohol Date: 1988 Jul-Aug Impact factor: 2.405

10. Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats.

Authors: J M Murphy; W J McBride; L Lumeng; T K Li
Journal: Alcohol Drug Res Date: 1987

65 in total

1. Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.

Authors: Amir H Rezvani; Susan Slade; Cori Wells; Ann Petro; Lawrence Lumeng; Ting-Kai Li; Yingxian Xiao; Milton L Brown; Mikell A Paige; Brian E McDowell; Jed E Rose; Kenneth J Kellar; Edward D Levin
Journal: Psychopharmacology (Berl) Date: 2010-06-10 Impact factor: 4.530

Review 2. Protein kinase C isozymes and addiction.

Authors: M Foster Olive; Robert O Messing
Journal: Mol Neurobiol Date: 2004-04 Impact factor: 5.590

3. The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism.

Authors: Sachin Moonat; Amul J Sakharkar; Huaibo Zhang; Subhash C Pandey
Journal: Addict Biol Date: 2010-12-23 Impact factor: 4.280

4. Increased ethanol consumption and preference in mice lacking neurotensin receptor type 2.

Authors: Moonnoh R Lee; David J Hinton; Sencan S Unal; Elliott Richelson; Doo-Sup Choi
Journal: Alcohol Clin Exp Res Date: 2010-10-06 Impact factor: 3.455

5. Combining naltrexone and prazosin in a single oral medication decreases alcohol drinking more effectively than does either drug alone.

Authors: Janice C Froehlich; Brett J Hausauer; Dennis D Rasmussen
Journal: Alcohol Clin Exp Res Date: 2013-07-22 Impact factor: 3.455

6. Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats.

Authors: Zachary A Rodd; Richard L Bell; Kelly A Kuc; James M Murphy; Lawrence Lumeng; William J McBride
Journal: Addict Biol Date: 2008-12-12 Impact factor: 4.280

7. Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours.

Authors: Amul J Sakharkar; Huaibo Zhang; Lei Tang; Kathryn Baxstrom; Guangbin Shi; Sachin Moonat; Subhash C Pandey
Journal: Int J Neuropsychopharmacol Date: 2014-02-17 Impact factor: 5.176

8. Early ethanol and water intake: choice mechanism and total fluid regulation operate in parallel in male alcohol preferring (P) and both Wistar and Sprague Dawley rats.

Authors: Alexey V Azarov; Donald J Woodward
Journal: Physiol Behav Date: 2013-10-02

9. Escalation of intravenous cocaine self-administration, progressive-ratio performance, and reinstatement in rats selectively bred for high (HiS) and low (LoS) saccharin intake.

Authors: Andrew D Morgan; Nancy K Dess; Marilyn E Carroll
Journal: Psychopharmacology (Berl) Date: 2004-08-27 Impact factor: 4.530

Review 10. Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

Authors: Richard L Bell; Helen J K Sable; Giancarlo Colombo; Petri Hyytia; Zachary A Rodd; Lawrence Lumeng
Journal: Pharmacol Biochem Behav Date: 2012-07-25 Impact factor: 3.533