Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 An experimental approach to understanding the genetic and neurobiological basis of alcoholism.

Literature DB >> 1343448

An experimental approach to understanding the genetic and neurobiological basis of alcoholism.

T K Li¹, L Lumeng, W J McBride, J M Murphy.

Abstract

The development and characterization of an animal model to study mechanisms underlying abnormal alcohol-seeking behavior have been described. Raised by genetic means, it demonstrates the importance of genetic factors in this behavior. It has allowed the elucidation of neural pathways and neurotransmitter systems that subserve alcohol-seeking behavior. It offers the potential for screening new medications for the treatment of alcoholism, based upon these kinds of newly discovered knowledge.

Entities: Chemical Disease

Mesh：

Substances：
Ethanol

Year: 1993 PMID： 1343448 PMCID： PMC2376626

Source DB: PubMed Journal: Trans Am Clin Climatol Assoc ISSN： 0065-7778

56 in total

1. Effect of spontaneous ingestion of ethanol on brain dopamine metabolism.

Authors: F Fadda; E Mosca; G Colombo; G L Gessa
Journal: Life Sci Date: 1989 Impact factor: 5.037

2. The estimation of heritability for the self-selection of alcohol in the albino rat.

Authors: K Eriksson
Journal: Ann Med Exp Biol Fenn Date: 1969

3. Progress toward a voluntary oral consumption model of alcoholism.

Authors: T K Li; L Lumeng; W J McBride; M B Waller
Journal: Drug Alcohol Depend Date: 1979 Jan-Mar Impact factor: 4.492

4. Development of the National Institutes of Health genetically heterogeneous rat stock.

Authors: C Hansen; K Spuhler
Journal: Alcohol Clin Exp Res Date: 1984 Sep-Oct Impact factor: 3.455

5. Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats.

Authors: W J McBride; J M Murphy; L Lumeng; T K Li
Journal: Pharmacol Biochem Behav Date: 1988-08 Impact factor: 3.533

6. The development of metabolic tolerance in the alcohol-preferring P rats: comparison of forced and free-choice drinking of ethanol.

Authors: L Lumeng; T K Li
Journal: Pharmacol Biochem Behav Date: 1986-11 Impact factor: 3.533

7. Persistence of tolerance to a single dose of ethanol in the selectively-bred alcohol-preferring P rat.

Authors: G J Gatto; J M Murphy; M B Waller; W J McBride; L Lumeng; T K Li
Journal: Pharmacol Biochem Behav Date: 1987-09 Impact factor: 3.533

8. Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease.

Authors: A Shibuya; A Yoshida
Journal: Am J Hum Genet Date: 1988-11 Impact factor: 11.025

An experimental approach to understanding the genetic and neurobiological basis of alcoholism.

1. Effect of spontaneous ingestion of ethanol on brain dopamine metabolism.

2. The estimation of heritability for the self-selection of alcohol in the albino rat.

3. Progress toward a voluntary oral consumption model of alcoholism.

4. Development of the National Institutes of Health genetically heterogeneous rat stock.

5. Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats.

6. The development of metabolic tolerance in the alcohol-preferring P rats: comparison of forced and free-choice drinking of ethanol.

7. Persistence of tolerance to a single dose of ethanol in the selectively-bred alcohol-preferring P rat.

8. Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease.

9. Characteristics of ethanol tolerance in alcohol drinking (AA) and alcohol avoiding (ANA) rats.

10. Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and -nonpreferring lines of rats.

1. Mixtures of Sweeteners and Maltodextrin Enhance Flavor and Intake of Alcohol in Adolescent Rats.

2. Alcohol Drinking and Blood Alcohol Concentration Revisited.