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Literature DB >> 5001397

Anti-antibody activity of a monoclonal macroglobulin.

N L Warner, M R Mackenzie, H H Fudenberg.

Abstract

A monoclonal macroglobulin from a patient with Waldenström macroglobulinemia has been shown to have antiglobulin activity of a new type, namely, that of a true anti-antibody. The protein reacts with human, primate, and rabbit IgM and IgG, only when the target immunoglobulin is complexed to an antigen. The implications of the general findings of antiglobulin activity of monoclonal proteins is discussed in relation to the possible etiology of the disease.

Entities: Disease Species

Mesh：

Substances：

Year: 1971 PMID： 5001397 PMCID： PMC389540 DOI： 10.1073/pnas.68.11.2846

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

1. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors: F C GREENWOOD; W M HUNTER; J S GLOVER
Journal: Biochem J Date: 1963-10 Impact factor: 3.857

2. Action of papain on human serum globulins.

Authors: H F DEUTSCH; E R STIEHM; J I MORTON
Journal: J Biol Chem Date: 1961-08 Impact factor: 5.157

3. Macroglobulins and macroglobulinaemia.

Authors: I R MACKAY
Journal: Australas Ann Med Date: 1959-05

4. Studies of a Waldenstrom-type macroglobulin with rheumatoid factor properties.

Authors: J KRITZMAN; H G KUNKEL; J MCCARTHY; R C MELLORS
Journal: J Lab Clin Med Date: 1961-06

5. Blocking of the lymphocyte antigen receptor site with anti-immunoglobulin sera in vitro.

Authors: N L Warner; P Byrt; G L Ada
Journal: Nature Date: 1970-06-06 Impact factor: 49.962

6. Experimental approaches to homogenous antibody populations. Myeloma proteins with antihapten antibody activity.

Authors: H N Eisen; M C Michaelides; B J Underdown; E P Schulenburg; E S Simms
Journal: Fed Proc Date: 1970 Jan-Feb

7. Immunochemical studies of the reaction between a mouse myeloma macroglobulin and dextrans.

Authors: M A Leon; N M Young; K R McIntire
Journal: Biochemistry Date: 1970-02-17 Impact factor: 3.162

8. Experimental approaches to homogenous antibody populations. Mouse IgA myeloma proteins that bind polysaccharide antigens of enterobacterial origin.

Authors: M Potter
Journal: Fed Proc Date: 1970 Jan-Feb

Anti-antibody activity of a monoclonal macroglobulin.

1. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

2. Action of papain on human serum globulins.

3. Macroglobulins and macroglobulinaemia.

4. Studies of a Waldenstrom-type macroglobulin with rheumatoid factor properties.

5. Blocking of the lymphocyte antigen receptor site with anti-immunoglobulin sera in vitro.

6. Experimental approaches to homogenous antibody populations. Myeloma proteins with antihapten antibody activity.

7. Immunochemical studies of the reaction between a mouse myeloma macroglobulin and dextrans.

8. Experimental approaches to homogenous antibody populations. Mouse IgA myeloma proteins that bind polysaccharide antigens of enterobacterial origin.

9. Human M-proteins with antibody activity for nitrophenyl ligands.

10. Physical properties of the red cell agglutinins in acquired hemolytic anemia.

1. A monoclonal macroglobulin with antinuclear activity.

2. A sulfhydryl-rich IgM protein with multiple serological specificities.

3. An IgM monoclonal protein with multiple serological specificities.