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Literature DB >> 2443287

A sulfhydryl-rich IgM protein with multiple serological specificities.

G Merlini¹, O Zettervall, A Forsgren, M Galliano, A A Lindberg, S B Svenson, F Pavesi, I Turesson.

Abstract

A monoclonal IgM lambda protein from a patient (E.T.) suffering from a lymphocytic lymphoma agglutinated Salmonella typhi bacteria and uncoated acryl particles. The antigenic determinant on Salmonella typhi bacteria was found to be 0-12 (alpha-D-Galp-(1-2)-alpha-D-Manp) while the structure on acryl particles recognized by IgM ET has not been defined. Both binding sites for bacteria and acryl particle determinants are localized on the same IgM molecule. The uncommon affinity of this IgM protein for some divalent heavy metal ions led to the finding of an unusually high content of sulfhydryl groups in the Fab portion of the molecule.

Entities: Chemical Disease Species

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Year: 1987 PMID： 2443287 PMCID： PMC1542251

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

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References

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A sulfhydryl-rich IgM protein with multiple serological specificities.

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