Literature DB >> 115627

An IgM monoclonal protein with multiple serological specificities.

G Merlini, A Forsgren, I Turesson, O Zettervall.   

Abstract

An IgM lambda M-component with a false Wasserman reaction and 'false' rheumatoid factor activity from a patient suffering from a well-differentiated lymphocytic lymphoma is presented. The monoclonal protein showed antibody activity against cardiolipin and cross-reacted with acryl particles, not with human IgG. Both these activities were found in the Fab fragment. The reduction of the 19S IgM to 7S IgM subunits was responsible for a strong decrease in activity. The importance of the IgM quaternary structure in determining antibody affinity is emphasized.

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Year:  1979        PMID： 115627      PMCID： PMC1537822     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  16 in total

1.  The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.

Authors:  R R PORTER
Journal:  Biochem J       Date:  1959-09       Impact factor: 3.857

2.  Electrophoretic studies on sera containing high-titre cold haemagglutinins: identification of the antibody as the cause of an abnormal gamma 1 peak.

Authors:  W N CHRISTENSON; J V DACIE; B E CROUCHER; P A CHARLWOOD
Journal:  Br J Haematol       Date:  1957-07       Impact factor: 6.998

3.  [A micro-method of immuno-electrophoresis].

Authors:  J J SCHEIDEGGER
Journal:  Int Arch Allergy Appl Immunol       Date:  1955

4.  Antibody activity of human myeloma globulins.

Authors:  M Seligmann; J C Brouet
Journal:  Semin Hematol       Date:  1973-04       Impact factor: 3.851

5.  Determination of protein: a modification of the Lowry method that gives a linear photometric response.

Authors:  E F Hartree
Journal:  Anal Biochem       Date:  1972-08       Impact factor: 3.365

Review 6.  Myeloma proteins (M-components) with antibody-like activity.

Authors:  M Potter
Journal:  N Engl J Med       Date:  1971-04-15       Impact factor: 91.245

7.  Papain fragmentation of the subunits of human macroglobulin.

Authors:  K Onoue; T Kishimoto; Y Yamamura
Journal:  J Immunol       Date:  1967-02       Impact factor: 5.422

8.  Characterization of a human macroglobulin. 3. The products of tryptic digestion.

Authors:  F Miller; H Metzger
Journal:  J Biol Chem       Date:  1966-04-25       Impact factor: 5.157

9.  Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors:  G Mancini; A O Carbonara; J F Heremans
Journal:  Immunochemistry       Date:  1965-09

10.  Physical properties of the red cell agglutinins in acquired hemolytic anemia.

Authors:  H H FUDENBERG; H G KUNKEL
Journal:  J Exp Med       Date:  1957-11-01       Impact factor: 14.307
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  5 in total

1.  A sulfhydryl-rich IgM protein with multiple serological specificities.

Authors:  G Merlini; O Zettervall; A Forsgren; M Galliano; A A Lindberg; S B Svenson; F Pavesi; I Turesson
Journal:  Clin Exp Immunol       Date:  1987-07       Impact factor: 4.330

2.  Serum antibodies to Legionella agents in bronchial asthma.

Authors:  S Beer; I Boldur; R Kazak; S Avidan; Y Kannai
Journal:  Arch Dis Child       Date:  1985-03       Impact factor: 3.791

3.  Monoclonal IgM with anti-muscle tissue activity in a patient with Waldenström's macroglobulinaemia: secretion of identical immunoglobulin by the established lymphoid cell line.

Authors:  C Micouin; J M Seigneurin; J C Renversez; B Roussel; M Favre; D Leroux
Journal:  Clin Exp Immunol       Date:  1984-12       Impact factor: 4.330

4.  Solid-phase enzyme immunoassay for determination of antibodies to cytomegalovirus.

Authors:  R V Krishna; O H Meurman; T Ziegler; U H Krech
Journal:  J Clin Microbiol       Date:  1980-07       Impact factor: 5.948

5.  A prevalence study of antibodies to Legionella spp. in geriatric institutions.

Authors:  I Boldur; M Ergaz; D Sompolinsky
Journal:  J Hyg (Lond)       Date:  1984-02
  5 in total

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