Literature DB >> 4982356

Complement components required for virus neutralization by early immunoglobulin antibody.

W D Linscott, W E Levinson.   

Abstract

Virus neutralization by early antisera usually requires or is enhanced by the presence of complement. The particular components of the complement system which are needed for neutralization of Newcastle disease virus by early IgM antibodies were studied. It was found in this system that participation of only the first four of the nine complement components (C1, C2, C3, and C4) was necessary and sufficient for neutralization to occur. It was concluded that the role of complement in neutralization was most likely that of contributing bulk in the form of large protein molecules to the virus-antibody complex.

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Year:  1969        PMID： 4982356      PMCID： PMC223375          DOI： 10.1073/pnas.64.2.520

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  38 in total

1.  Further studies on the chemotactic factor of complement and its formation in vivo.

Authors:  P A Ward; C G Cochrane; H J Muller-Eberhard
Journal:  Immunology       Date:  1966-08       Impact factor: 7.397

2.  Radiation studies of avian tumor viruses and of Newcastle disease virus.

Authors:  W Levinson; H Rubin
Journal:  Virology       Date:  1966-04       Impact factor: 3.616

3.  Problems encountered in double diffusion analysis in agar of hapten specific immune systems. I. Complement dependent precipitation.

Authors:  W Paul; B Benacerraf
Journal:  J Immunol       Date:  1965-12       Impact factor: 5.422

4.  The isolation and characterization of a ninth component of hemolytic complement, C'3f.

Authors:  K Inoue; R A Nelson
Journal:  J Immunol       Date:  1966-03       Impact factor: 5.422

5.  Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates.

Authors:  R M Stroud; K F Austen; M M Mayer
Journal:  Immunochemistry       Date:  1965-09

6.  Phage-neutralizing activity in light polypeptide chains of rabbit antibody.

Authors:  J W Goodman; J J Donch
Journal:  Immunochemistry       Date:  1965-12

7.  Complement fixation on cell surfaces by 19S and 7S antibodies.

Authors:  T Borsos; H J Rapp
Journal:  Science       Date:  1965-10-22       Impact factor: 47.728

8.  A new concept of immunosuppression in hypersensitivity reactions and in transplantation immunity.

Authors:  R A Nelson
Journal:  Surv Ophthalmol       Date:  1966-08       Impact factor: 6.048

9.  Deficiency of the sixth component of complement in rabbits with an inherited complement defect.

Authors:  K Rother; U Rother; H J Müller-Eberhard; J R Nilsson
Journal:  J Exp Med       Date:  1966-10-01       Impact factor: 14.307

10.  The reaction mechanism of beta-1C-globulin (C'3) in immune hemolysis.

Authors:  H J Müllerèberhard; A P Dalmasso; M A Calcott
Journal:  J Exp Med       Date:  1966-01-01       Impact factor: 14.307
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  33 in total

1.  Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity.

Authors:  Jerome P Jayasekera; E Ashley Moseman; Michael C Carroll
Journal:  J Virol       Date:  2007-01-03       Impact factor: 5.103

2.  Selection of unique antigenic variants of Newcastle disease virus with neutralizing monoclonal antibodies and anti-immunoglobulin.

Authors:  R M Iorio; M A Bratt
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

3.  Formation and biologic role of polyoma virus-antibody complexes. A critical role for complement.

Authors:  M B Oldstone; N R Cooper; D L Larson
Journal:  J Exp Med       Date:  1974-08-01       Impact factor: 14.307

4.  The influence of complement on cytomegalovirus neutralization by antibodies.

Authors:  H K Andersen
Journal:  Arch Gesamte Virusforsch       Date:  1972

5.  Inhibitors against rabies virus present in normal rabbit sera.

Authors:  N Sekine; K Yoshino
Journal:  Arch Gesamte Virusforsch       Date:  1974

6.  Neutralization of infectious ME (Maus-Elberfeld) virus-antibody complexes by anti-gamma-globulin antibody.

Authors:  J Cihak
Journal:  Med Microbiol Immunol       Date:  1973-09-26       Impact factor: 3.402

7.  Complement protein C1q reduces the stoichiometric threshold for antibody-mediated neutralization of West Nile virus.

Authors:  Erin Mehlhop; Steevenson Nelson; Christiane A Jost; Sergey Gorlatov; Syd Johnson; Daved H Fremont; Michael S Diamond; Theodore C Pierson
Journal:  Cell Host Microbe       Date:  2009-10-22       Impact factor: 21.023

8.  The influence of complement on the neutralization of infectious bovine rhinotracheitis virus by globulins derived from early and late bovine antisera.

Authors:  L N Potgieter
Journal:  Can J Comp Med       Date:  1975-10

9.  Neutralization of Epstein-Barr virus by nonimmune human serum. Role of cross-reacting antibody to herpes simplex virus and complement.

Authors:  G R Nemerow; F C Jensen; N R Cooper
Journal:  J Clin Invest       Date:  1982-11       Impact factor: 14.808

10.  Measurement of modulation of mouse complement levels in vivo, utilizing a microtiter hemolytic assay.

Authors:  K L White; A C Anderson
Journal:  Agents Actions       Date:  1984-12
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