| Literature DB >> 4367757 |
M B Oldstone, N R Cooper, D L Larson.
Abstract
Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence has been gathered that C1 through C3 and not C5 through C9 enhance neutralization of virus-antiviral antibody (V-Ab) complexes. C enhancement of neutralization occurs primarily by agglutination of V-Ab complexes and not by virion lysis or attachment of large protein molecules to the V-Ab complex. In this model, binding of C1, 4, 2, 3 to the V-Ab complex may explain why some viruses concentrate in or infect certain cells bearing C3 receptors such as B lymphocytes, macrophages, and monocytes.Entities:
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Year: 1974 PMID： 4367757 PMCID： PMC2139595 DOI： 10.1084/jem.140.2.549
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307