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Literature DB >> 5922290

Deficiency of the sixth component of complement in rabbits with an inherited complement defect.

K Rother, U Rother, H J Müller-Eberhard, J R Nilsson.

Abstract

A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form.

Entities: Disease Species

Mesh：

Substances：

Year: 1966 PMID： 5922290 PMCID： PMC2138255 DOI： 10.1084/jem.124.4.773

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

16 in total

1. PROLONGED SURVIVAL OF SKIN HOMOGRAFTS IN RABBITS DEFECTIVE IN THE THIRD COMPONENT OF COMPLEMENT.

Authors: H VOLK; D MAUERSBERGER; K ROTHER; U ROTHER
Journal: Ann N Y Acad Sci Date: 1964-11-30 Impact factor: 5.691

2. Activity of mouse complement.

Authors: L T ROSENBERG; D K TACHIBANA
Journal: J Immunol Date: 1962-12 Impact factor: 5.422

3. Starch gel electrophoresis in a discontinous system of buffers.

Authors: M D POULIK
Journal: Nature Date: 1957-12-28 Impact factor: 49.962

4. A method of trace iodination of proteins for immunologic studies.

Authors: P J McConahey; F J Dixon
Journal: Int Arch Allergy Appl Immunol Date: 1966

5. Further studies on the chemotactic factor of complement and its formation in vivo.

Authors: P A Ward; C G Cochrane; H J Muller-Eberhard
Journal: Immunology Date: 1966-08 Impact factor: 7.397

6. Studies on complement defective rabbits. IV. Blood clearance of intravenously injected S. typhi by the reticuloendothelial system.

Authors: K Rother; U Rother
Journal: Proc Soc Exp Biol Med Date: 1965 Aug-Sep

7. Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum.

Authors: R A Nelson; J Jensen; I Gigli; N Tamura
Journal: Immunochemistry Date: 1966-03

8. COMPONENTS OF GUINEA PIG COMPLEMENT. I. SEPARATION OF A SERUM FRACTION ESSENTIAL FOR IMMUNE HEMOLYSIS AND IMMUNE ADHERENCE.

Authors: K NISHIOKA; W D LINSCOTT
Journal: J Exp Med Date: 1963-11-01 Impact factor: 14.307

9. DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT.

Authors: B CINADER; S DUBISKI; A C WARDLAW
Journal: J Exp Med Date: 1964-11-01 Impact factor: 14.307

10. EXPERIMENTAL GLOMERULONEPHRITIS. IV. PARTICIPATION OF COMPLEMENT IN NEPHROTOXIC NEPHRITIS.

Authors: E UNANUE; F J DIXON
Journal: J Exp Med Date: 1964-01-01 Impact factor: 14.307

32 in total

Review 1. Complement deficiency.

Authors: K M O'Neil
Journal: Clin Rev Allergy Immunol Date: 2000-10 Impact factor: 8.667

Deficiency of the sixth component of complement in rabbits with an inherited complement defect.

1. PROLONGED SURVIVAL OF SKIN HOMOGRAFTS IN RABBITS DEFECTIVE IN THE THIRD COMPONENT OF COMPLEMENT.

2. Activity of mouse complement.

3. Starch gel electrophoresis in a discontinous system of buffers.

4. A method of trace iodination of proteins for immunologic studies.

5. Further studies on the chemotactic factor of complement and its formation in vivo.

6. Studies on complement defective rabbits. IV. Blood clearance of intravenously injected S. typhi by the reticuloendothelial system.

7. Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum.

8. COMPONENTS OF GUINEA PIG COMPLEMENT. I. SEPARATION OF A SERUM FRACTION ESSENTIAL FOR IMMUNE HEMOLYSIS AND IMMUNE ADHERENCE.

9. DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT.

10. EXPERIMENTAL GLOMERULONEPHRITIS. IV. PARTICIPATION OF COMPLEMENT IN NEPHROTOXIC NEPHRITIS.

Review 1. Complement deficiency.

2. Hypochlorite-induced alterations to canine serum complement.

3. A unique complement derived chemotactic factor for tumor cells.

Review 4. Animal models of inherited complement deficiency.

5. Neutralization of sensitized virus by purified components of complement.

6. Studies on the mode of action of the fifth, sixth and seventh component of human complement in immune haemolysis.

7. A new complement-mediated cytolytic mechanism--the C1-bypass activation pathway.

8. Formation of C'-6 by rabbit liver tissue in vitro.

9. The role of complement in localized shwartzman reaction: studies with congenitally C6-deficient rabbits.

10. Hereditary C6 deficiency in a strain of PVG/c rats.