Literature DB >> 5319759

Complement fixation on cell surfaces by 19S and 7S antibodies.

T Borsos, H J Rapp.   

Abstract

The mechanism of complement fixation on cell surfaces by whole antiserums, and by 19S and 7S fractions has been studied with a new comple-ment-fixation test. This test is based on the fixation and transfer of the activated first component of complement (C1a). We have concluded that a single molecule of 19S antibody in combination with antigen at the cell surface is sufficient to bind one molecule of C1a. For 7S antibodies at least two molecules in close proximity at the cell surface are required to fix one molecule of C1a.

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Year:  1965        PMID： 5319759     DOI： 10.1126/science.150.3695.505

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  70 in total

1.  Binding characteristics of M and L isoantibodies to high and low potassium sheep red cells.

Authors:  P K Lauf; W W Sun
Journal:  J Membr Biol       Date:  1976-09-17       Impact factor: 1.843

2.  Antibodies-structure and biological function.

Authors:  J H Humphrey
Journal:  Proc R Soc Med       Date:  1967-06

3.  Activation of antibody Fc function by antigen-induced conformational changes.

Authors:  J C Brown; M E Koshland
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

4.  Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms.

Authors:  Kirstie L S Cleary; H T Claude Chan; Sonja James; Martin J Glennie; Mark S Cragg
Journal:  J Immunol       Date:  2017-04-12       Impact factor: 5.422

5.  Potent human immunodeficiency virus-neutralizing and complement lysis activities of antibodies are not obligatorily linked.

Authors:  Michael Huber; Viktor von Wyl; Christoph G Ammann; Herbert Kuster; Gabriela Stiegler; Hermann Katinger; Rainer Weber; Marek Fischer; Heribert Stoiber; Huldrych F Günthard; Alexandra Trkola
Journal:  J Virol       Date:  2008-01-30       Impact factor: 5.103

6.  Effect of rheumatoid factor and anti-immunoglobulin G antibodies on complement-mediated lysis of herpes simplex virus-infected human fibroblasts.

Authors:  J C Shivers; C A Daniels
Journal:  Infect Immun       Date:  1977-02       Impact factor: 3.441

Review 7.  Immunopathologic events at the endplate in myasthenia gravis.

Authors:  T Ashizawa; S H Appel
Journal:  Springer Semin Immunopathol       Date:  1985

8.  Specific secondary biological properties of purified rabbit immunoglobulin M and immunoglobulin G antibodies to Brucella abortus and Bordetella pertussis.

Authors:  M L Schulkind; M Herzberg; J B Robbins
Journal:  Infect Immun       Date:  1971-09       Impact factor: 3.441

9.  The detection of cell-bound antibody on complement-coated human red cells.

Authors:  B C Gilliland; J P Leddy; J H Vaughan
Journal:  J Clin Invest       Date:  1970-05       Impact factor: 14.808

10.  Fixation of the first component of complement (C'la) by human antibodies.

Authors:  W F Rosse
Journal:  J Clin Invest       Date:  1969-11       Impact factor: 14.808
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