Literature DB >> 48779

Doxantrazole, an antiallergic agent orally effective in man.

J F Batchelor, M J Follenfant, L G Garland, J H Gorvin, A F Green, H F Hodson, D T Hughes, J E Tateson.   

Abstract

In-vivo studies have demonstrated antiallergic properties in doxantrazole when given orally to rats. These properties were confirmed in work with in-vitro preparations. No significant animal toxicity has been detected. 200 mg. given by mouth inhibited the immediate-type asthmatic response in volunteer patients challenged with specific antigen.

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Year:  1975        PMID: 48779     DOI: 10.1016/s0140-6736(75)93141-4

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  13 in total

1.  Trial of doxantrazole in asthma.

Authors:  H R Gribbin; J E Harvey; A E Tattersfield
Journal:  Br Med J       Date:  1979-01-13

2.  Inhibitory effect of oral doxantrazole on asthma induced by allergen inhalation.

Authors:  S P Haydu; J L Bradley; D T Hughes
Journal:  Br Med J       Date:  1975-08-02

3.  Effects of [N-(2-oxo-3,5,7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) on cyclic 3',5'-nucleotide formation and phosphodiesterase activity.

Authors:  T A Pugsley; W Lippmann
Journal:  Experientia       Date:  1979-01-15

4.  New orally effective chromosome derivatives for the treatment of asthma.

Authors:  J Augstein; H Cairns; D Hunter; T B Lee; J Suschitzky; R E Altounyan; D M Jackson; J Mann; T S Orr; P Sheard
Journal:  Agents Actions       Date:  1977-10

5.  Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents.

Authors:  Laurent Ferrier; Florian Bérard; Laurent Debrauwer; Chantal Chabo; Philippe Langella; Lionel Buéno; Jean Fioramonti
Journal:  Am J Pathol       Date:  2006-04       Impact factor: 4.307

6.  Exercise-induced asthma and doxantrazole.

Authors:  H Poppius; B Stenius
Journal:  Eur J Clin Pharmacol       Date:  1977-01-03       Impact factor: 2.953

Review 7.  The mucosal mast cell and its role in gastrointestinal allergic diseases.

Authors:  K E Barrett; D D Metcalfe
Journal:  Clin Rev Allergy       Date:  1984-02

8.  Mathematical prediction of drug distribution in vivo: studies with doxantrazole in rats.

Authors:  I C Caldwell; S Mahmood; M Weatherall
Journal:  J Pharmacokinet Biopharm       Date:  1978-12

9.  Cromoglycate and other antiallergic drugs: a possible mechanism of action.

Authors:  J C Foreman; L G Garland
Journal:  Br Med J       Date:  1976-04-03

10.  Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells.

Authors:  F De Clerck; J Van Reempts; M Borgers
Journal:  Agents Actions       Date:  1981-05
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