Literature DB >> 930755

New orally effective chromosome derivatives for the treatment of asthma.

J Augstein, H Cairns, D Hunter, T B Lee, J Suschitzky, R E Altounyan, D M Jackson, J Mann, T S Orr, P Sheard.   

Abstract

Two new chromone derivatives have been identified which possess oral anti-allergic activity in the rat PCA model of immediate hypersensitivity. They may have a wider spectrum of anti-allergic activity than disodium cromoglycate (SCG) since they are effective in in vitro tests involving sensitized basophils, in which SCG is inactive. Both compounds, when given orally, provide relief from experimental and clinical asthma in man.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 930755     DOI： 10.1007/bf01966850

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  Inhibition of immediate hypersensitivity reactions by disodium cromoglycate.

Authors:  D S Thomson; D P Evans
Journal:  Clin Exp Immunol       Date:  1973-04       Impact factor: 4.330

2.  Degranulation of human basophil leukocytes by anti-gamma E antibody.

Authors:  T Ishizaka; H Tomioka; K Ishizaka
Journal:  J Immunol       Date:  1971-03       Impact factor: 5.422

3.  Passive cutaneous anaphylaxis in the rat, induced with two homologous reagin-like antibodies and its specific inhibition with disodium cromoglycate.

Authors:  J Goose; A M Blair
Journal:  Immunology       Date:  1969-06       Impact factor: 7.397

4.  Histamine release from human leukocytes by anti-gamma E antibodies.

Authors:  T Ishizaka; K Ishizaka; S G Johansson; H Bennich
Journal:  J Immunol       Date:  1969-04       Impact factor: 5.422

Review 5.  Disodium cromoglycate (Intal).

Authors:  J S Cox; J E Beach; A M Blair; A J Clarke; J King; T B Lee; D E Loveday; G F Moss; T S Orr; J T Ritchie; P Sheard
Journal:  Adv Drug Res       Date:  1970

6.  Inhibition of allergic reactions by cromoglycate and by AH 7079 in patients with allergic airway disease.

Authors:  E S Assem; M K McAllen
Journal:  Int Arch Allergy Appl Immunol       Date:  1973

7.  The effect of predosage with disodium cromoglycate (DSCG) on the dose-related inhibition of rat passive cutaneous anaphylaxis by DSCG.

Authors:  P A Riley; P Sheard; A J Clarke; T S Orr
Journal:  Life Sci       Date:  1975-09-01       Impact factor: 5.037

8.  Doxantrazole, an antiallergic agent orally effective in man.

Authors:  J F Batchelor; M J Follenfant; L G Garland; J H Gorvin; A F Green; H F Hodson; D T Hughes; J E Tateson
Journal:  Lancet       Date:  1975-05-24       Impact factor: 79.321

9.  Inhibition of experimental asthma in man by a new drug (AH 7725) active when given by mouth.

Authors:  E S Assem; J A Evans; M McAllen
Journal:  Br Med J       Date:  1974-04-13
  9 in total
  7 in total

1.  The effect of lodoxamide ethyl [diethyl N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate] on in vivo anaphylactic reactions.

Authors:  H G Johnson; R L Griffin; J B Wright
Journal:  Agents Actions       Date:  1979-08

2.  The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs.

Authors:  W Kreutner; J Sherwood; C Rizzo
Journal:  Agents Actions       Date:  1989-11

3.  A one-pot three-component reaction involving 2-aminochromone in aqueous micellar medium: a green synthesis of hexahydrochromeno[2,3-b]quinolinedione.

Authors:  Jaydip Ghosh; Pritam Biswas; Michael G B Drew; Chandrakanta Bandyopadhyay
Journal:  Mol Divers       Date:  2015-03-11       Impact factor: 2.943

4.  The activity of sodium cromoglycate analogues in human lung in vitro: a comparison with rat passive cutaneous anaphylaxis and clinical efficacy.

Authors:  M K Church; C F Gradidge
Journal:  Br J Pharmacol       Date:  1980-10       Impact factor: 8.739

5.  Metabolism and clearance of proxicromil--studies in rat, hamster, rabbit, dog, squirrel monkey, cynomolgus monkey, baboon and man.

Authors:  D A Smith; M G Neale
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1983 Jul-Sep       Impact factor: 2.441

6.  The pharmacology of isamoxole [2-methyl-n-butyl-n(4-methyloxazol-2-yl) propanamide] LRCL 3950, a new anti-allergic compound.

Authors:  W Dawson; W J Sweatman
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

7.  The activity of an anti-allergic compound, proxicromil, on models of immunity and inflammation.

Authors:  R W Keogh; R V Bundick; P G Cunnington; S N Jenkins; A Blackham; T S Orr
Journal:  Agents Actions       Date:  1981-07
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.