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Literature DB >> 6167156

Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells.

Abstract

Oxatomide inhibits the release of histamine from rat peritoneal mast cells in vitro induced by C 48/80, antigen, anti-IgE and ionophore A 23 187, without effect on non-specific release by n-decylamine. Its effect is concentration- and pH-dependent and decreases with increasing extracellular Ca2+-concentrations. Prolonged incubation does not enhance the inhibition, which is lost after one single wash-out. Aminophylline and isoproterenol are not potentiated by oxatomide. The present study points to an effect of oxatomide on a Ca2+-dependent process at the level of cell membrane common to antigen, C 48/80 and ionophore A 23 187.

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Year: 1981 PMID： 6167156 DOI： 10.1007/BF01967612

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

39 in total

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Authors: R P Siraganian
Journal: J Immunol Methods Date: 1975-06 Impact factor: 2.303

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Authors: E A BOYSE; L J OLD; I CHOUROULINKOV
Journal: Methods Med Res Date: 1964

3. Inhibition and stimulation of histamine release by oxatomide.

Authors: C W Bierman; E S Assem; J L Mongar
Journal: Int J Immunopharmacol Date: 1979

4. Degranulation of rat mesentery mast cells by antihistamines: influence of ionization.

Authors: J J Pini; I Vugman
Journal: Agents Actions Date: 1978-10

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Authors: F Awouters; C J Niemegeers; J Van den Berk; J M Van Neuten; F M Lenaerts; M Borgers; K H Schellekens; A Broeckaert; J De Cree; P A Janssen
Journal: Experientia Date: 1977-12-15

6. Anti-allergic actions of disodium cromoglycate and other drugs known to inhibit cyclic 3',5'-nucleotide phosphodiesterase.

Authors: W A Taylor; D H Francis; D Sheldon; I M Roitt
Journal: Int Arch Allergy Appl Immunol Date: 1974

7. Inhibitory action of 6-ethyl-3-(1H-tetrazol-5-YL)chromone (AA-344) on IgE, IgGa- or chemical agent-induced histamine release from isolated rat mast cells.

Authors: T Saijo; Y Ashida; H Kuriki; M Kanno; Y Maki
Journal: Jpn J Pharmacol Date: 1979-08

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Authors: E Gillespie; L M Lichtenstein
Journal: J Clin Invest Date: 1972-11 Impact factor: 14.808

9. The interaction of calcium and strontium with phosphatidyl serine in the anaphylactic secretion of histamine.

Authors: J C Foreman; J L Mongar
Journal: J Physiol Date: 1973-04 Impact factor: 5.182

10. Movement of calcium ions and release of histamine from rat mast cells.

Authors: N S Ranadive; N Dhanani
Journal: Int Arch Allergy Appl Immunol Date: 1980

5 in total

1. Suppression of PAF-induced bronchoconstriction in the guinea-pig by oxatomide: mechanism of action.

Authors: F P Nijkamp; G Folkerts; J R Beetens; F De Clerck
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1989-07 Impact factor: 3.000

2. Oxatomide protects against degranulation of rat peritoneal mast cells during in vitro challenge with antigen or compound 48/80. Ultrastructural aspects.

Authors: J Van Reempts; F De Clerck; M Borgers
Journal: Agents Actions Date: 1981-05