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Literature DB >> 4791301

Biosynthesis of monensin.

L E Day, J W Chamberlin, E Z Gordee, S Chen, M Gorman, R L Hamill, T Ness, R E Weeks, R Stroshane.

Abstract

The biosynthesis of monensin by Streptomyces cinnamonensis was studied by using (14)C-labeled glucose, acetate, propionate, butyrate, and methionine. The results indicated that the antibiotic is synthesized from five acetate, seven propionate, and one butyrate molecules. The o-methyl group of monensin is derived from methionine, whereas the terminal hydroxymethyl group is incorporated from acetate.

Entities: Chemical Species

Mesh：

Substances：

Year: 1973 PMID： 4791301 PMCID： PMC444568 DOI： 10.1128/AAC.4.4.410

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

5 in total

1. The biosynthesis of the macrolide antibiotic lucensomycin.

Authors: D G Manwaring; R W Rickards; G Gaudiano; V Nicolella
Journal: J Antibiot (Tokyo) Date: 1969-11 Impact factor: 2.649

2. The structure of monensic acid, a new biologically active compound.

Authors: A Agtarap; J W Chamberlin; M Pinkerton; L Steinrauf
Journal: J Am Chem Soc Date: 1967-10-25 Impact factor: 15.419

3. Monensin, a new biologically active compound. II. Fermentation studies.

Authors: W M Stark; N G Knox; J E Westhead
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1967

4. Monensin, a new biologically active compound. I. Discovery and isolation.

Authors: M E Haney; M M Hoehn
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1967

5. Monensin, a new biologically active compound. IV. Chemistry.

Authors: A Agtarap; J W Chamberlin
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1967

5 in total

14 in total

1. Deregulation of acetohydroxy-acid synthase: Loss of allosteric inhibition conferred by mutations in the catalytic subunit.

Authors: J Kopecký; M Kyselková; L Sigutová; S Pospísil; J Felsberg; J Spízek; J Janata
Journal: Folia Microbiol (Praha) Date: 2009-04-18 Impact factor: 2.099

Review 2. Biosynthesis of polyketide synthase extender units.

Authors: Yolande A Chan; Angela M Podevels; Brian M Kevany; Michael G Thomas
Journal: Nat Prod Rep Date: 2009-01 Impact factor: 13.423

Review 3. Are There Any Other Compounds Isolated From Dermacoccus spp at All?

Authors: Manaf AlMatar; Mohamed Eldeeb; Essam A Makky; Fatih Köksal; Işıl Var; Begüm Kayar
Journal: Curr Microbiol Date: 2016-10-26 Impact factor: 2.188

4. Restriction of bacteriophage plaque formation in Streptomyces spp.

Authors: K L Cox; R H Baltz
Journal: J Bacteriol Date: 1984-08 Impact factor: 3.490

5. Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone.

Authors: S Pospísil; P Sedmera; V Havlícek; J Tax
Journal: Appl Environ Microbiol Date: 1994-05 Impact factor: 4.792

6. Regulation of biosynthesis of monensins on chemically defined medium.

Authors: S Pospísil; E Královcová; K Stajner; J Tax; V Krumphanzl; Z Vanĕk
Journal: Folia Microbiol (Praha) Date: 1982 Impact factor: 2.099

7. Effect of precursors on biosynthesis of monensins A and B.

Authors: S Pospísil; E Cimburková; V Krumphanzl; Z Vanĕk
Journal: Folia Microbiol (Praha) Date: 1985 Impact factor: 2.099

8. Propionate and the production of monensins in Streptomyces cinnamonensis.

Authors: J Matĕjů; J Karnetová; M Nohýnek; Z Vanĕk
Journal: Folia Microbiol (Praha) Date: 1988 Impact factor: 2.099

Review 9. Epoxide-opening cascades in the synthesis of polycyclic polyether natural products.

Authors: Ivan Vilotijevic; Timothy F Jamison
Journal: Angew Chem Int Ed Engl Date: 2009 Impact factor: 15.336

10. Biosynthesis of monensins A and B: the role of isoleucine.

Authors: S Pospísil; P Sedmera; V Krumphanzl; Z Vanĕk
Journal: Folia Microbiol (Praha) Date: 1986 Impact factor: 2.099