Literature DB >> 8017935

Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone.

S Pospísil1, P Sedmera, V Havlícek, J Tax.   

Abstract

Metyrapone, a potent cytochrome P-450 inhibitor, added at 9 mM to a submerged culture of Streptomyces cinnamonensis caused partial inhibition of total monensin biosynthesis and coproduction of new metabolites, 26-deoxymonensins A and B. The latter was isolated as its 25-O-methyl derivative. Metyrapone was simultaneously reduced to metyrapol. All of these compounds were identified by nuclear magnetic resonance spectroscopy and mass spectrometry.

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Year:  1994        PMID： 8017935      PMCID： PMC201517          DOI： 10.1128/aem.60.5.1561-1564.1994

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  11 in total

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