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Literature DB >> 475945

The activity of aryl hydrocarbon hydroxylase in adult human skin.

Abstract

1 Aryl hydrocarbon hydroxylase (AHH), a mixed-function oxidase system, has been identified in microsomal preparations of adult breast skin and foreskin. 2 Separation of dermis from epidermis by stretching, showed that AHH activity in human skin is almost exclusively located within the epidermis. 3 Preincubation of whole chopped skin with benzanthracene (5 muM to 100 muM) using a tissue culture system was accompanied by a concentration dependent increase in AHH activity. 4 Although there was no significant difference in AHH activity between the two sites, individuals differed markedly from one another in activity at any one site. Activity was observed to be positively correlated with age.

Entities: Chemical Gene Species

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Year: 1979 PMID： 475945 PMCID： PMC1429572 DOI： 10.1111/j.1365-2125.1979.tb00993.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

13 in total

1. Induction of aryl hydrocarbon hydroxylase and carbon monoxide-binding hemoproteins in mouse epidermis by tobacco carcinogens.

Authors: W P Norred; F J Akin
Journal: Biochem Pharmacol Date: 1976-03-15 Impact factor: 5.858

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. Cancer susceptibility and carcinogen metabolism.

Authors: H V Gelboin
Journal: N Engl J Med Date: 1977-08-18 Impact factor: 91.245

4. Inducibility of benzo( )pyrene hydroxylase in human skin by polycylic hydrocarbons.

Authors: A P Alvares; A Kappas; W Levin; A H Conney
Journal: Clin Pharmacol Ther Date: 1973 Jan-Feb Impact factor: 6.875

5. Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme.

Authors: D W Nebert; H V Gelboin
Journal: J Biol Chem Date: 1968-12-10 Impact factor: 5.157

6. Cytochromes P-450 and b5 in human liver microsomes.

Authors: A P Alvares; G Schilling; W Levin; R Kuntzman; L Brand; L C Mark
Journal: Clin Pharmacol Ther Date: 1969 Sep-Oct Impact factor: 6.875

7. The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters.

Authors: R Eisenthal; A Cornish-Bowden
Journal: Biochem J Date: 1974-06 Impact factor: 3.857

8. Specificity of human, rat and mouse skin epoxide hydratase towards K-region epoxides of polycyclic hydrocarbons.

Authors: F Oesch; H Schmassmann; P Bentley
Journal: Biochem Pharmacol Date: 1978-01-01 Impact factor: 5.858

Review 9. Pharmacokinetics in the elderly.

Authors: J Crooks; K O'Malley; I H Stevenson
Journal: Clin Pharmacokinet Date: 1976 Impact factor: 6.447

The activity of aryl hydrocarbon hydroxylase in adult human skin.

1. Induction of aryl hydrocarbon hydroxylase and carbon monoxide-binding hemoproteins in mouse epidermis by tobacco carcinogens.

2. Protein measurement with the Folin phenol reagent.

3. Cancer susceptibility and carcinogen metabolism.

4. Inducibility of benzo( )pyrene hydroxylase in human skin by polycylic hydrocarbons.

5. Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme.

6. Cytochromes P-450 and b5 in human liver microsomes.

7. The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters.

8. Specificity of human, rat and mouse skin epoxide hydratase towards K-region epoxides of polycyclic hydrocarbons.

Review 9. Pharmacokinetics in the elderly.

10. Induction of aryl hydrocarbon hydroxylase in human pulmonary alveolar macrophages by cigarette smoking.

1. Cytochrome P-450-dependent O-dealkylase activity in mammalian skin.

2. Polymorphic 4-hydroxylation of debrisoquine in chronic discoid psoriasis.

3. Human epidermal blister: a convenient tissue for toxicological and genetic studies of benzo(a)pyrene metabolism.

4. Epoxide hydrolase activity in human skin.

5. Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture.

6. Generalised tissue abnormality of aryl hydrocarbon hydroxylase in psoriasis.