Literature DB >> 3740942

Human epidermal blister: a convenient tissue for toxicological and genetic studies of benzo(a)pyrene metabolism.

J Van Cantfort, T Lorand, J E Gielen, C M Lapière.   

Abstract

Benzo(a)pyrene (BP) metabolism has been studied in epidermal blisters maintained in a culture medium for 24 h and 48 h. The viability of the cells has been assayed by [3H]proline incorporation into proteins and by [14C]BP metabolism into unconjugated metabolites. A screen of BP metabolism in 19 individuals shows a great variation of basal epidermal activity. Induction of BP metabolism by the application of coal tar 24 h before the epidermal blister sampling, resulted in two- to eight-fold increase in BP metabolism. This induction is not increased when the coal tar application is repeated.

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Year:  1986        PMID： 3740942     DOI： 10.1007/bf00407747

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  19 in total

1.  Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological importance.

Authors:  J Van Cantfort; J De Graeve; J E Gielen
Journal:  Biochem Biophys Res Commun       Date:  1977-11-21       Impact factor: 3.575

2.  The role of epidermal aryl hydrocarbon hydroxylase in the covalent binding of polycyclic hydrocarbon to DNA and its relationship to tumor initiation.

Authors:  S G Buty; S Thompson; T J Slaga
Journal:  Biochem Biophys Res Commun       Date:  1976-06-21       Impact factor: 3.575

3.  A new highly sensitive assay for ethoxycoumarin deethylase in cultured hepatocytes.

Authors:  J De Graeve; P Kremers; C Frankinet; J Gielen
Journal:  Anal Biochem       Date:  1980-05-15       Impact factor: 3.365

4.  Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene.

Authors:  M D Burke; R T Mayer
Journal:  Drug Metab Dispos       Date:  1974 Nov-Dec       Impact factor: 3.922

5.  Metabolism of benzo[a]pyrene in human epidermal keratinocytes in culture.

Authors:  T Kuroki; N Nemoto; Y Kitano
Journal:  Carcinogenesis       Date:  1980-07       Impact factor: 4.944

6.  Aryl hydrocarbon hydroxylase activity and psoriasis.

Authors:  M J Finnen; S Shuster; C M Lawrence; M D Rawlins
Journal:  Biochem Pharmacol       Date:  1983-06-01       Impact factor: 5.858

7.  Decreased epidermal aryl hydrocarbon hydroxylase and localized pustular psoriasis.

Authors:  S Shuster; M D Rawlins; P H Chapman; S Rogers
Journal:  Br J Dermatol       Date:  1980-07       Impact factor: 9.302

8.  The activity of aryl hydrocarbon hydroxylase in adult human skin.

Authors:  P H Chapman; M D Rawlins; S Shuster
Journal:  Br J Clin Pharmacol       Date:  1979-05       Impact factor: 4.335

9.  Human skin aryl hydrocarbon hydroxylase. Induction by coal tar.

Authors:  D R Bickers; A Kappas
Journal:  J Clin Invest       Date:  1978-11       Impact factor: 14.808

10.  Significant variation in mouse-skin aryl hydrocarbon hydroxylase inducibility as a function of the hair growth cycle.

Authors:  L Manil; J Van Cantfort; C M Lapière; J E Gielen
Journal:  Br J Cancer       Date:  1981-02       Impact factor: 7.640
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