Literature DB >> 6978749

Cytochrome P-450-dependent O-dealkylase activity in mammalian skin.

F J Damen, P D Mier.   

Abstract

1 A modified technique for the measurement of O-dealkylase (ODA) activity in crude homogenates is reported, and its application to skin is described. 2 Large differences in ODA levels were found between different species, no activity being observed in the skin of primates. 3 Induction of cutaneous ODA in mice was achieved by the subcutaneous injection of phenobarbitone, hexachlorobenzene or 20-methylcholanthrene. 4 Attempts to induce ODA in vitro were unsuccessful.

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Year:  1982        PMID： 6978749      PMCID： PMC2071456          DOI： 10.1111/j.1476-5381.1982.tb08764.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  The O-dealkylation of 7-ethoxycoumarin by liver microsomes. A direct fluorometric test.

Authors:  V Ullrich; P Weber
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1972-07

2.  Phenobarbital inducible drug monooxygenase activity in the small intestine of mice.

Authors:  C Lehrmann; V Ullrich; W Rummel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

3.  Cutaneous cytochrome P-450 activity during hexachlorobenzene-induced experimental porphyria in rats.

Authors:  G Goerz; W Vizethum; D Tsambaos
Journal:  Arch Dermatol Res       Date:  1979-05-29       Impact factor: 3.017

4.  An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors:  W F Greenlee; A Poland
Journal:  J Pharmacol Exp Ther       Date:  1978-06       Impact factor: 4.030

5.  Characteristics of a microsomal cytochrome P-448-mediated reaction. Ethoxyresorufin O-de-ethylation.

Authors:  M D Burke; R A Prough; R T Mayer
Journal:  Drug Metab Dispos       Date:  1977 Jan-Feb       Impact factor: 3.922

6.  Cytochrome P-450 content and mixed-function oxidase activity in microsomes isolated from mouse skin.

Authors:  R J Pohl; R M Philpot; J R Fouts
Journal:  Drug Metab Dispos       Date:  1976 Sep-Oct       Impact factor: 3.922

7.  Generalised tissue abnormality of aryl hydrocarbon hydroxylase in psoriasis.

Authors:  P H Chapman; P J Kersey; B Keys; S Shuster; M D Rawlins
Journal:  Br Med J       Date:  1980-11-15

8.  The activity of aryl hydrocarbon hydroxylase in adult human skin.

Authors:  P H Chapman; M D Rawlins; S Shuster
Journal:  Br J Clin Pharmacol       Date:  1979-05       Impact factor: 4.335
  8 in total
  4 in total

Review 1.  Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:  F Oesch; E Fabian; Robert Landsiedel
Journal:  Arch Toxicol       Date:  2018-06-18       Impact factor: 5.153

2.  The role of cytoplasmic free calcium in the responses of quin2-loaded human platelets to vasopressin.

Authors:  T J Hallam; N T Thompson; M C Scrutton; T J Rink
Journal:  Biochem J       Date:  1984-08-01       Impact factor: 3.857

Review 3.  Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:  F Oesch; E Fabian; K Guth; R Landsiedel
Journal:  Arch Toxicol       Date:  2014-11-05       Impact factor: 5.153

4.  Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets.

Authors:  W K Pollock; D E MacIntyre
Journal:  Biochem J       Date:  1986-02-15       Impact factor: 3.857
  4 in total

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