Literature DB >> 4718114

Infertility in female rabbits immunized with lactate dehydrogenase X.

E Goldberg.   

Abstract

Immunization of female rabbits with the sperm-specific lactate dehydrogenase (LDH-X) resulted in a highly significant reduction of pregnancies compared to nonimmunized controls. This is the first demonstration of immunosuppression of fertility by a crystalline protein shown to be strictly homogeneous by ultracentrifugation, polyacrylamide gel electrophoresis, immunodiffusion, and micro complement fixation.

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Year:  1973        PMID： 4718114     DOI： 10.1126/science.181.4098.458

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Immunological approaches to fertility regulation.

Authors:  V C Stevens
Journal:  Bull World Health Organ       Date:  1978       Impact factor: 9.408

2.  Isolation of human lactate dehydrogenase isoenzyme X by affinity chromatography.

Authors:  A H Kolk; L van Kuyk; B Boettcher
Journal:  Biochem J       Date:  1978-09-01       Impact factor: 3.857

3.  Expression of the cDNA encoding for mouse sperm-specific lactate dehydrogenase C in Chinese-hamster ovary cells.

Authors:  E W Hou; I Sakai; S S Li
Journal:  Biochem J       Date:  1987-10-01       Impact factor: 3.857

Review 4.  Current trends in antifertility vaccine research.

Authors:  D C Covey; K D O'Brien; D E Moore
Journal:  West J Med       Date:  1985-02

5.  Characterization of monoclonal antibodies to the sperm-specific lactate dehydrogenase isozyme.

Authors:  R E Goldman-Leikin; E Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

Review 6.  LDHC: the ultimate testis-specific gene.

Authors:  Erwin Goldberg; Edward M Eddy; Chongwen Duan; Fanny Odet
Journal:  J Androl       Date:  2009-10-29

7.  Rapid purification of lactate dehydrogenase X from mouse testes by two steps of affinity chromatography on oxamate-sepharose.

Authors:  H Spielmann; H G Eibs; C Mentzel
Journal:  Experientia       Date:  1976-08-15

8.  Molecular cloning and nucleotide sequence of the cDNA for sperm-specific lactate dehydrogenase-C from mouse.

Authors:  I Sakai; F S Sharief; S S Li
Journal:  Biochem J       Date:  1987-03-01       Impact factor: 3.857

9.  Immunocontraceptive target repertoire defined by systematic identification of sperm membrane alloantigens in a single species.

Authors:  Nathaly Cormier; John J McGlone; John Leszyk; Daniel M Hardy
Journal:  PLoS One       Date:  2018-01-17       Impact factor: 3.240
  9 in total

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