Literature DB >> 4686465

Amphotericin B methyl ester hydrochloride and amphotericin B: comparative acute toxicity.

G R Keim, J W Poutsiaka, J Kirpan, C H Keysser.   

Abstract

In single-dose parenteral studies with mice and dogs, the methyl ester hydrochloride of amphotericin B proved to be significantly less toxic than the parent compound, especially to the kidney.

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Year:  1973        PMID： 4686465     DOI： 10.1126/science.179.4073.584

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

Review 1.  New antifungal therapy in ophthalmology.

Authors:  T W Lieberman; I H Leopold
Journal:  Trans Am Ophthalmol Soc       Date:  1973

2.  Antifungal activity of some substituted pyrimidines.

Authors:  J D McChesney; M Gonzalez-Sierra
Journal:  Pharm Res       Date:  1985-05       Impact factor: 4.200

3.  Comparative in vitro antifungal activity of amphotericin B and amphotericin B methyl ester.

Authors:  W R Howarth; R P Tewari; M Solotorovsky
Journal:  Antimicrob Agents Chemother       Date:  1975-01       Impact factor: 5.191

4.  Antiviral effects of amphotericin B methyl ester.

Authors:  G W Jordan; E C Seet
Journal:  Antimicrob Agents Chemother       Date:  1978-02       Impact factor: 5.191

5.  Chemotherapy of experimental endogenous Candida albicans endophthalmitis.

Authors:  D B Jones
Journal:  Trans Am Ophthalmol Soc       Date:  1980

6.  Sterol-polyene antibiotic complexation: probe of membrane structure.

Authors:  R Bittman
Journal:  Lipids       Date:  1978-10       Impact factor: 1.880

7.  Comparative susceptibility of four kinds of pathogenic fungi to amphotericin B and amphotericin B methyl ester.

Authors:  A C Huston; P D Hoeprich
Journal:  Antimicrob Agents Chemother       Date:  1978-06       Impact factor: 5.191

8.  C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells.

Authors:  Brandon C Wilcock; Matthew M Endo; Brice E Uno; Martin D Burke
Journal:  J Am Chem Soc       Date:  2013-06-03       Impact factor: 15.419

9.  The effect of fetal bovine serum on polyene macrolide antibiotic cytotoxicity and antifungal activity.

Authors:  D P Bonner; P B Fisher; N I Goldstein; W Mechlinski; V Bryson; C P Schaffner
Journal:  In Vitro       Date:  1976-05

10.  Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs.

Authors:  G R Keim; P L Sibley; Y H Yoon; J S Kulesza; I H Zaidi; M M Miller; J W Poutsiaka
Journal:  Antimicrob Agents Chemother       Date:  1976-10       Impact factor: 5.191
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