Literature DB >> 4525464

Molecular heterosis for heat-sensitive enzyme alleles.

R S Singh, J L Hubby, R C Lewontin.   

Abstract

Heat denaturation studies were carried out and revealed hidden genic variants with the same net charge at the Octanol dehydrogenase-1 locus in Drosophila pseudoobscura. Studies of several genetic crosses between strains with different heat-sensitivity alleles showed that the F(1) retained more in vitro enzyme activity after being heat-treated for a specified amount of time at a given temperature than the heat-resistant parent. We call this phenomenon "heterosis for heat-stability of enzyme activity" and discuss its possible molecular mechanism, its relation to maintenance of genetic variation in natural populations, and its bearing on the "classical" and "balance" hypotheses.

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Year:  1974        PMID： 4525464      PMCID： PMC388330          DOI： 10.1073/pnas.71.5.1808

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  4 in total

1.  Still more genetic variability in natural populations.

Authors:  S C Bernstein; L H Throckmorton; J L Hubby
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

2.  Isozyme specificity to temperature.

Authors:  K K Pandey
Journal:  Nat New Biol       Date:  1972-09-06

Review 3.  Electrophoretic variation in enzymes.

Authors:  C R Shaw
Journal:  Science       Date:  1965-08-27       Impact factor: 47.728

4.  A molecular approach to the study of genic heterozygosity in natural populations. IV. Patterns of genic variation in central, marginal and isolated populations of Drosophila pseudoobscura.

Authors:  S Prakash; R C Lewontin; J L Hubby
Journal:  Genetics       Date:  1969-04       Impact factor: 4.562
  4 in total
  26 in total

1.  Epigenetics of dominance for enzyme activity.

Authors:  Kuldip S Trehan; Kulbir S Gill
Journal:  J Biosci       Date:  2002-03       Impact factor: 1.826

2.  The charge-state model of protein polymorphism in natural populations.

Authors:  D R Marshall; A H Brown
Journal:  J Mol Evol       Date:  1975-11-04       Impact factor: 2.395

3.  Alcohol dehydrogenase polymorphism in populations of Drosophila melanogaster. II. Relation between ADH activity and adult mortality.

Authors:  A Kamping; W van Delden
Journal:  Biochem Genet       Date:  1978-06       Impact factor: 1.890

4.  Variation between electrophoretically identical alleles at the alcohol dehydrogenase locus in Drosophila melanogaster.

Authors:  E W Thörig; A A Schoone; W Scharloo
Journal:  Biochem Genet       Date:  1975-10       Impact factor: 1.890

5.  The study of genic variation by electrophoretic and heat denaturation techniques at the octanol dehydrogenase locus in members of the Drosophila virilis group.

Authors:  R S Singh; J L Hubby; L H Throckmorton
Journal:  Genetics       Date:  1975-07       Impact factor: 4.562

6.  Patterns of molecular variation. I. Interspecific comparisons of electromorphs in the Drosophila mulleri complex.

Authors:  R H Richardson; P E Smouse
Journal:  Biochem Genet       Date:  1976-06       Impact factor: 1.890

7.  Characterization of electrophoretically cryptic variation in the alpine butterfly Colias meadii.

Authors:  G B Johnson
Journal:  Biochem Genet       Date:  1977-08       Impact factor: 1.890

8.  Substrate-specific enzyme variation in natural populations of Drosophila pseudoobscura.

Authors:  R S Singh
Journal:  Genetics       Date:  1976-03-25       Impact factor: 4.562

9.  Further evidence of thermostability variation within electrophoretic mobility classes of enzymes.

Authors:  R Milkman
Journal:  Biochem Genet       Date:  1976-04       Impact factor: 1.890

10.  Genetic variation in Hawaiian Drosophila. VIII. Heterozygosity and genic changes in isolated populations of D. engyochracea.

Authors:  W W Steiner
Journal:  Biochem Genet       Date:  1979-08       Impact factor: 1.890
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