Literature DB >> 4521219

Still more genetic variability in natural populations.

S C Bernstein, L H Throckmorton, J L Hubby.   

Abstract

Heat-denaturation studies of xanthine dehydrogenase have revealed many more additional alleles at the locus controlling this enzyme than are revealed by electrophoretic studies. In natural populations of species in the virilis group of the genus Drosophila, heat-denaturation studies of flies from the same locality revealed 1.74 times as many alleles as did electrophoretic studies. Similarly, studies of several species over their geographic range also revealed 1.74 times as many alleles. In addition, for the nine species studied, electrophoretic analysis had revealed only 11 alleles within the group, whereas heat-denaturation studies revealed a total of 32 alleles. These findings are discussed in the light of the continuing controversy over Darwinian and non-Darwinian theories of evolution.

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Year:  1973        PMID： 4521219      PMCID： PMC427359          DOI： 10.1073/pnas.70.12.3928

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  An electrophoretic study of mutationally altered A proteins of the tryptophan synthetase of Escherichia coli.

Authors:  U HENNING; C YANOFSKY
Journal:  J Mol Biol       Date:  1963-01       Impact factor: 5.469

2.  A genetic study of two new structural forms of tyrosinase in Neurospora.

Authors:  N H HOROWITZ; M FLING; H MACLEOD; N SUEOKA
Journal:  Genetics       Date:  1961-08       Impact factor: 4.562

3.  Enzyme polymorphisms in man.

Authors:  H Harris
Journal:  Proc R Soc Lond B Biol Sci       Date:  1966-03-22

4.  A molecular approach to the study of genic heterozygosity in natural populations. IV. Patterns of genic variation in central, marginal and isolated populations of Drosophila pseudoobscura.

Authors:  S Prakash; R C Lewontin; J L Hubby
Journal:  Genetics       Date:  1969-04       Impact factor: 4.562

5.  Esterase heterogeneity: dynamics of a polymorphism.

Authors:  R K Koehn
Journal:  Science       Date:  1969-02-28       Impact factor: 47.728

6.  Genetic regulation of xanthine dehydrogenase in Drosophila melanogaster.

Authors:  E Glassman
Journal:  Fed Proc       Date:  1965 Sep-Oct

Review 7.  Polymorphism and protein evolution. The neutral mutation-random drift hypothesis.

Authors:  H Harris
Journal:  J Med Genet       Date:  1971-12       Impact factor: 6.318

8.  A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura.

Authors:  J L Hubby; R C Lewontin
Journal:  Genetics       Date:  1966-08       Impact factor: 4.562

9.  A molecular approach to the study of genic heterozygosity in natural populations. II. Amount of variation and degree of heterozygosity in natural populations of Drosophila pseudoobscura.

Authors:  R C Lewontin; J L Hubby
Journal:  Genetics       Date:  1966-08       Impact factor: 4.562

10.  Microgeographical Variation in Allozyme Frequencies in Avena barbata.

Authors:  J L Hamrick; R W Allard
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205
  10 in total
  53 in total

1.  The charge-state model of protein polymorphism in natural populations.

Authors:  D R Marshall; A H Brown
Journal:  J Mol Evol       Date:  1975-11-04       Impact factor: 2.395

2.  Alcohol dehydrogenase polymorphism in populations of Drosophila melanogaster. II. Relation between ADH activity and adult mortality.

Authors:  A Kamping; W van Delden
Journal:  Biochem Genet       Date:  1978-06       Impact factor: 1.890

3.  Electrophoretically silent alleles in a finite population.

Authors:  M Nei; R Chakraborty
Journal:  J Mol Evol       Date:  1976-12-30       Impact factor: 2.395

4.  Allelic heterogeneity within allozymes separated by electrophoresis in Drosophila pseudoobscura.

Authors:  R E McDowell; S Prakash
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

5.  The spatial distribution of transient alleles in a subdivided population: a simulation study.

Authors:  M Slatkin; D Charlesworth
Journal:  Genetics       Date:  1978-08       Impact factor: 4.562

6.  Variation between electrophoretically identical alleles at the alcohol dehydrogenase locus in Drosophila melanogaster.

Authors:  E W Thörig; A A Schoone; W Scharloo
Journal:  Biochem Genet       Date:  1975-10       Impact factor: 1.890

7.  Hidden alleles at the alpha-glycerophosphate dehydrogenase locus in Colias butterflies.

Authors:  G B Johnson
Journal:  Genetics       Date:  1976-05       Impact factor: 4.562

8.  The study of genic variation by electrophoretic and heat denaturation techniques at the octanol dehydrogenase locus in members of the Drosophila virilis group.

Authors:  R S Singh; J L Hubby; L H Throckmorton
Journal:  Genetics       Date:  1975-07       Impact factor: 4.562

9.  Further evidence of thermostability variation within electrophoretic mobility classes of enzymes.

Authors:  R Milkman
Journal:  Biochem Genet       Date:  1976-04       Impact factor: 1.890

10.  The purification and biochemical properties of alcohol dehydrogenase--"fast (Chateau Douglas)" from Drosophila melanogaster.

Authors:  G K Chambers
Journal:  Biochem Genet       Date:  1984-06       Impact factor: 1.890
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