Literature DB >> 44657

Utilization of the perfused stomach in anaesthetized rats to study the inhibitory effect of somatostatin in gastric acid secretion.

M J Robein, M C de la Mare, J M Dubrasquet, S Bonfils.   

Abstract

The perfused stomach in the anaesthetized rat was used to investigate the action of somatostatin on the gastric acid secretion stimulated by gastrin, histamine and carbamylcholine. Evidence is produced that somatostatin competitively inhibits gastrin-stimulated acid secretion whereas it inhibits carbamylcholine-stimulated acid secretion by a mechanism which is non-competitive in nature and it has no action on histamine-stimulated secretion. The model of the persued stomach in the anaesthetized rat seems suitable to study the inhibition caused by drug on stimulated acid secretion.

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Year:  1979        PMID： 44657     DOI： 10.1007/bf01968104

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  21 in total

1.  Action of somatostatin and metiamide on gastric acid secretion from isolated bullfrog gastric mucosa.

Authors:  M W Warrick; T M Lin
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1976-01

2.  Continuous recording of acid gastric secretion in the rat.

Authors:  M N GHOSH; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1958-03

3.  Effect of somatostatin analogs on gastric and pancreatic secretion.

Authors:  S J Konturek; J Tasler; R Krol; A Dembinski; D H Coy; A V Schally
Journal:  Proc Soc Exp Biol Med       Date:  1977-09

4.  Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone.

Authors:  S R Bloom; C H Mortimer; M O Thorner; G M Besser; R Hall; A Gomez-Pan; V M Roy; R C Russell; D H Coy; A J Kastin; A V Schally
Journal:  Lancet       Date:  1974-11-09       Impact factor: 79.321

5.  Direct inhibition of gastric acid by growth-hormone release-inhibiting hormone in dogs.

Authors:  A A Barros D'Sa; S R Bloom; J H Baron
Journal:  Lancet       Date:  1975-04-19       Impact factor: 79.321

6.  Inhibition by somatostatin of gastrin release and gastric acid responses to meals and to pentagastrin in man.

Authors:  J Phillip; S Domschke; W Domschke; H J Urbach; M Reiss; L Demling
Journal:  Scand J Gastroenterol       Date:  1977       Impact factor: 2.423

7.  Effect of growth hormone release-inhibiting hormone on gastric secretion, mucosal blood flow, and serum gastrin.

Authors:  S J Konturek; J Tasler; M Cieszkowski; D H Coy; A V Schally
Journal:  Gastroenterology       Date:  1976-05       Impact factor: 22.682

8.  The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat.

Authors:  M Albinus; E L Blair; B H Hirst; J D Reed; A V Schally; B Shaw
Journal:  J Physiol       Date:  1977-04       Impact factor: 5.182

9.  Inhibition by somatostatin (growth-hormone release-inhibiting hormone, GH-RIH) of gastric acid and pepsin and G-cell release of gastrin.

Authors:  A A Barros D'sa; S R Bloom; J H Baron
Journal:  Gut       Date:  1978-04       Impact factor: 23.059

10.  Somatostatin mode of action on gastric acid secretion in dogs.

Authors:  H Hummelt; H M Jennewein; R Treichel; F Waldeck
Journal:  Digestion       Date:  1977-02       Impact factor: 3.216
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  3 in total

1.  Cholinergic control of gastric acid secretion.

Authors:  F Pagani; A Brambilla; A Schiavone; A Giachetti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-03       Impact factor: 3.000

2.  Growth-hormone releasing factor does not antagonize somatostatin effects on pancreatic and gastric secretions.

Authors:  M Chovet; M Dubrasquet; J Chariot; C Rozé
Journal:  Experientia       Date:  1985-11-15

3.  Effect of somatostatin, secretin, and glucagon on secretagogue stimulated aminopyrine uptake in isolated canine parietal cells.

Authors:  E Perez-Reyes; N A Payne; J G Gerber
Journal:  Agents Actions       Date:  1983-06
  3 in total

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