| Literature DB >> 47535 |
A A Barros D'Sa, S R Bloom, J H Baron.
Abstract
To find out if growth-hormone release-inhibiting hormone (G.H.-R.I.H.) had any direct action on gastric acid production independent of its effect on gastrin release, cyclic G.H.-R.I.H. was infused at a rate of 20 mug. per kg. per hour into dogs with gastric fistulae. Gastric acid output fell sharply in response to three stimuli acid production--a meal and pentagastrin and histamine infusions. The fact that acid output was inhibited during pentagastrin administration suggests that G.H.-R.I.H. has a direct action on the gastric parietal cell.Entities:
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Year: 1975 PMID： 47535 DOI： 10.1016/s0140-6736(75)91685-2
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321