Literature DB >> 838187

Somatostatin mode of action on gastric acid secretion in dogs.

H Hummelt, H M Jennewein, R Treichel, F Waldeck.   

Abstract

The aim of the present study was to investigate the mode of the inhibitory effect of somatostatin on gastric acid secretion. This was done in Heidenhain-pouch dogs studying the effect of somatostatin on cumulative dose response curves of pentagastrin, carbachol and histamine. Somatostatin inhibited gastric secretion after all three stimuli, with decreasing potency against carbachol, pentagastrin and histamine. The pentagastrin-stimulated acid secretion was inhibited in a noncompetitive way; in contrary to this the carbachol and also the histamine-stimulated secretion was inhibited in a competitive way.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 838187     DOI： 10.1159/000197996

Source DB:  PubMed          Journal:  Digestion        ISSN： 0012-2823            Impact factor:   3.216


  7 in total

1.  The somatostatin/histaminic pathway balance on gastric secretion could be based on a competitive antagonism.

Authors:  J Vatier; C Poitevin; W Riquet; M T Vitre; A Olivier; P Martin; S Bonfils
Journal:  Agents Actions       Date:  1988-07

2.  Somatostatin-receptor 2 (sst2)-mediated effects of endogenous somatostatin on exocrine and endocrine secretion of the rat stomach.

Authors:  Vidar Fykse; David H Coy; Helge Lyder Waldum; Arne Kristian Sandvik
Journal:  Br J Pharmacol       Date:  2005-02       Impact factor: 8.739

3.  Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat.

Authors:  M Moriga; K Kojima; M Aono; H Uchino; H Yajima
Journal:  Gastroenterol Jpn       Date:  1978

4.  Tachyphylaxis of the ECL-cell response to PACAP: receptor desensitization and/or depletion of secretory products.

Authors:  M Bernsand; R Håkanson; P Norlén
Journal:  Br J Pharmacol       Date:  2007-07-30       Impact factor: 8.739

5.  Effect of somatostatin, secretin, and glucagon on secretagogue stimulated aminopyrine uptake in isolated canine parietal cells.

Authors:  E Perez-Reyes; N A Payne; J G Gerber
Journal:  Agents Actions       Date:  1983-06

6.  Histamine is able to suppress the inhibitory effect of somatostatin on exogenous gastrin: comparison between extractive antral histamine and synthetic histamine.

Authors:  J Vatier; C Poitevin; J C Robert; S Bonfils
Journal:  Agents Actions       Date:  1983-02

7.  Utilization of the perfused stomach in anaesthetized rats to study the inhibitory effect of somatostatin in gastric acid secretion.

Authors:  M J Robein; M C de la Mare; J M Dubrasquet; S Bonfils
Journal:  Agents Actions       Date:  1979-12
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.