Literature DB >> 4441380

Insulin release from the perfused rat pancreas. Mode of action of tolbutamide.

V Bowen, N R Lazarus.   

Abstract

Dextran-linked tolbutamide causes first-phase insulin release when perfused through the isolated rat pancreas. The linked sulphonylurea is also able to stimulate the membranal adenylate cyclase present in mouse islets. These facts make it highly likely that sulphonylureas exert their pharmacological action by interaction with the plasma membrane. Their action may be mediated via the adenylate cyclase enzyme.

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Year:  1974        PMID： 4441380      PMCID： PMC1168290          DOI： 10.1042/bj1420385

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  Cyclic nucleotide phosphodiesterase activity in normal mouse pancreatic islets.

Authors:  S J.H. Ashcroft; P J. Randle; I -B. Täljedal
Journal:  FEBS Lett       Date:  1972-02-15       Impact factor: 4.124

2.  Glucose-mediated insulin release: 3',5' cAMP phosphodiesterase.

Authors:  V Bowen; N R Lazaus
Journal:  Diabetes       Date:  1973-10       Impact factor: 9.461

3.  Factors which influence cyclic AMP formation and degradation in an islet cell tumor of the Syrian hamster.

Authors:  O M Rosen; A H Hirsch; E N Goren
Journal:  Arch Biochem Biophys       Date:  1971-10       Impact factor: 4.013

4.  [Six years' experience with a musculoplastic technic].

Authors:  T Atkins; A J Matty
Journal:  J Endocrinol       Date:  1971-09       Impact factor: 4.286

5.  The pancreatic -cell recognition of insulin secretagogues. IV. Islet uptake of sulfonylureas.

Authors:  B Hellman; J Sehlin; I B Täljedal
Journal:  Diabetologia       Date:  1973-06       Impact factor: 10.122

6.  The pancreatic beta-cell recognition of insulin secretagogues. Inhibitory effects of a membrane probe on the islet uptake and insulin-releasing action of glibenclamide.

Authors:  B Hellman; A Lernmark; J Sehlin; I B Töljedal
Journal:  FEBS Lett       Date:  1973-08-15       Impact factor: 4.124

7.  Adenylate cyclase in islets of Langerhans. Isolation of islets and regulation of adenylate cyclase activity by various hormones and agents.

Authors:  W N Kuo; D S Hodgins; J F Kuo
Journal:  J Biol Chem       Date:  1973-04-25       Impact factor: 5.157

8.  The pancreatic -cell recognition of insulin secretagogues. II. Site of action of tolbutamide.

Authors:  B Hellman; J Sehlin; I B Töljedal
Journal:  Biochem Biophys Res Commun       Date:  1971-12-17       Impact factor: 3.575

9.  Insulin release from mouse islets. Effect of glucose and hormones on adenylate cyclase.

Authors:  B Davis; N R Lazarus
Journal:  Biochem J       Date:  1972-09       Impact factor: 3.857
  9 in total
  8 in total

1.  Effects of polymer-linked sulfonylurea derivatives on insulin release.

Authors:  H G Joost; A Hasselblatt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-03       Impact factor: 3.000

2.  The beta-cell glibenclamide receptor is an ADP-binding protein.

Authors:  I Niki; J L Nicks; S J Ashcroft
Journal:  Biochem J       Date:  1990-06-15       Impact factor: 3.857

3.  Tolbutamide-induced changes of the DNA, protein and insulin content and the secretory activity of isolated rat pancreatic islets.

Authors:  P Schauder; H Frerichs
Journal:  Diabetologia       Date:  1975-08       Impact factor: 10.122

4.  Long-term effects of glibenclamide on the insulin production, oxidative metabolism and quantitative ultrastructure of mouse pancreatic islets maintained in tissue culture at different glucose concentrations.

Authors:  L A Håkan Borg; A Andersson
Journal:  Acta Diabetol Lat       Date:  1981

5.  The control of 86Rb efflux from rat isolated pancreatic islets by the sulphonylureas tolbutamide and glibenclamide.

Authors:  E K Matthews; P A Shotton
Journal:  Br J Pharmacol       Date:  1984-07       Impact factor: 8.739

6.  Uptake of tolbutamide by islets of Langerhans and other tissues.

Authors:  H G Joost; S Holze
Journal:  Experientia       Date:  1978-10-15

7.  Effect of methylene blue and thiol oxidants on pancreatic islet GSH/GSSG ratios and tolbutamide mediated insulin release in vitro.

Authors:  H P Ammon; M S Akhtar; A Grimm; H Niklas
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-05       Impact factor: 3.000

8.  Dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas.

Authors:  C F Gotfredsen
Journal:  Diabetologia       Date:  1976-08       Impact factor: 10.122
  8 in total

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