| Literature DB >> 134920 |
Abstract
In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, and glisoxepide, which were all alike in terms of the relationship between first and second phases of insulin release.Entities:
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Year: 1976 PMID： 134920 DOI： 10.1007/bf00420977
Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122