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Literature DB >> 1107120

Tolbutamide-induced changes of the DNA, protein and insulin content and the secretory activity of isolated rat pancreatic islets.

Abstract

Following prolonged administration of tolbutamide the DNA- and protein content per islet was enhanced but the IRI content per islet was diminished. Glucose-induced (2.0, 8.0 or 16.6 mM) and leucine-induced (12.5 or 25.0 mM) IRI release from isolated islets, as well as 14C02-production from U-14C glucose, were decreased. Theophylline (5.0 mM) restored the glucose sensitivity of the islets towards normal. The results indicate that tolbutamide-induced islet cell hyperplasia does not entail islet hyperfunction, as previously thought. Decreased IRI release may partially be explained by a tolbutamide-induced alteration of the adenylate cyclase/phosphodiesterase system of the B-cell.

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Year: 1975 PMID： 1107120 DOI： 10.1007/bf00422395

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

41 in total

1. B CELL HYPERFUNCTION AFTER LONG-TERM SULFONYLUREA TREATMENT.

Authors: B W VOLK; S S LAZARUS
Journal: Arch Pathol Date: 1964-08

2. [Morphological findings on the mode of action of oral antidiabetics].

Authors: J KRACHT; C VON HOLT; L VON HOLT
Journal: Endokrinologie Date: 1957

3. [Histological study of the effect of the hypoglycemic sulphamides on the islands of Langerhans of the rat; study of the effect of BZ-55 treatment associated with cortisone].

Authors: W GEPTS
Journal: Ann Endocrinol (Paris) Date: 1957 Impact factor: 2.478

8. The stimulatory effect on insulin secretion in long-term tolbutamide treatment. Immunological determinations of urinary- and serum insulin.

Authors: K Johansen; H Orskov
Journal: Acta Endocrinol (Copenh) Date: 1972-12

9. Adenylate cyclase in islets of Langerhans. Isolation of islets and regulation of adenylate cyclase activity by various hormones and agents.

Authors: W N Kuo; D S Hodgins; J F Kuo
Journal: J Biol Chem Date: 1973-04-25 Impact factor: 5.157

10. An inhibitory effect of tolbutamide and glibenclamide (glyburide) on the pancreatic islets of normal animals.

Authors: J C Dunbar; P P Foà
Journal: Diabetologia Date: 1974-02 Impact factor: 10.122

4 in total

1. Long-term effects of glibenclamide on the insulin production, oxidative metabolism and quantitative ultrastructure of mouse pancreatic islets maintained in tissue culture at different glucose concentrations.

Authors: L A Håkan Borg; A Andersson
Journal: Acta Diabetol Lat Date: 1981

Tolbutamide-induced changes of the DNA, protein and insulin content and the secretory activity of isolated rat pancreatic islets.

1. B CELL HYPERFUNCTION AFTER LONG-TERM SULFONYLUREA TREATMENT.

2. [Morphological findings on the mode of action of oral antidiabetics].

3. [Histological study of the effect of the hypoglycemic sulphamides on the islands of Langerhans of the rat; study of the effect of BZ-55 treatment associated with cortisone].

4. Cytochalasin B: inhibition of glucose-induced insulin release from isolated rat pancreatic islets.

5. [Isolation of Langerhans' islets from rat pancreas].

6. [The effect of oral antidiabetics on the biosynthesis of proinsulin in the rat].

7. Inhibition of glucose and tolbutamide-induced insulin release by iodoacetate and antimycin A.

8. The stimulatory effect on insulin secretion in long-term tolbutamide treatment. Immunological determinations of urinary- and serum insulin.

9. Adenylate cyclase in islets of Langerhans. Isolation of islets and regulation of adenylate cyclase activity by various hormones and agents.

10. An inhibitory effect of tolbutamide and glibenclamide (glyburide) on the pancreatic islets of normal animals.

1. Long-term effects of glibenclamide on the insulin production, oxidative metabolism and quantitative ultrastructure of mouse pancreatic islets maintained in tissue culture at different glucose concentrations.

2. Insulin secretion and (pro)insulin biosynthesis of cultured mice islets after glibenclamide loading in vitro.

3. Plasma insulin and glucose levels in maturity onset diabetics treated with chlorpropamide.

4. Cytochalasin B: evidence for a membrane-directed action in B-cells from rat pancreatic islets.