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Literature DB >> 4159522

Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus.

A L Notkins, S E Mergenhagen, A A Rizzo, C Scheele, T A Waldmann.

Abstract

Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of gamma-globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human gamma-globulin showed that the capacity of the virus-infected animal to produce anti-human gamma-globulin was greatly enhanced and that the virus acted as an adjuvant. From these experiments it is concluded that a virus infection (LDV) can affect the immunologic response of the host to a heterologous antigen.

Entities: Disease Species

Mesh：

Substances：

Year: 1966 PMID： 4159522 PMCID： PMC2138136 DOI： 10.1084/jem.123.2.347

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

33 in total

1. ACTION OF RILEY'S PLASMA ENZYME-ELEVATING VIRUS IN MICE.

Authors: B W MAHY
Journal: Virology Date: 1964-11 Impact factor: 3.616

2. TOLERANCE TO A PROTEIN ANTIGEN IN ADULT MICE AND THE EFFECT OF NONSPECIFIC FACTORS.

Authors: H N CLAMAN
Journal: J Immunol Date: 1963-12 Impact factor: 5.422

3. STUDIES ON THE ADJUVANT ACTION OF BACTERIAL ENDOTOXINS ON ANTIBODY FORMATION. VI. ENHANCEMENT OF ANTIBODY FORMATION BY NUCLEIC ACIDS.

Authors: K MERRITT; A G JOHNSON
Journal: J Immunol Date: 1965-03 Impact factor: 5.422

Review 4. LACTIC DEHYDROGENASE VIRUS.

Authors: A L NOTKINS
Journal: Bacteriol Rev Date: 1965-06

5. Human serum macroglobulins and dissociation units. I. Physicochemical properties.

Authors: H F DEUTSCH; J I MORTON
Journal: J Biol Chem Date: 1958-04 Impact factor: 5.157

6. Antigen elimination from the blood as an early manifestation of the immune response.

Authors: D W TALMAGE; F J DIXON; S C BUKANTZ; G J DAMMIN
Journal: J Immunol Date: 1951-10 Impact factor: 5.422

7. Sensitivity of passive haemagglutination for assay of 7S and 19S antibodies in primary rabbit anti-bovine serum albumin sera.

Authors: A A Benedict
Journal: Nature Date: 1965-06-26 Impact factor: 49.962

8. Maintenance of globulin levels in x-irradiated rabbits after immunization.

Authors: M B RITTENBERG; E L NELSON
Journal: Science Date: 1962-10-26 Impact factor: 47.728

9. ULTRASTRUCTURE OF THE LACTIC DEHYDROGENASE VIRUS (LDV) AND CELL-VIRUS RELATIONSHIPS.

Authors: G DETHE; A L NOTKINS
Journal: Virology Date: 1965-07 Impact factor: 3.616

10. THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION.

Authors: S E SVEHAG; B MANDEL
Journal: J Exp Med Date: 1964-01-01 Impact factor: 14.307

21 in total

1. Antibody-producing cells: virus-induced alteration of response to antigen.

Authors: V Riley; W Braun; M Ishizuka; D Spackman
Journal: Proc Natl Acad Sci U S A Date: 1976-05 Impact factor: 11.205

2. Immune responses in mice infected with lactic dehydrogenase virus. I. Antibody response to DNP-BGG and hyperglobulinaemia in BALB/c mice.

Authors: M C Michaelides; E S Simms
Journal: Immunology Date: 1977-06 Impact factor: 7.397

Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus.

1. ACTION OF RILEY'S PLASMA ENZYME-ELEVATING VIRUS IN MICE.

2. TOLERANCE TO A PROTEIN ANTIGEN IN ADULT MICE AND THE EFFECT OF NONSPECIFIC FACTORS.

3. STUDIES ON THE ADJUVANT ACTION OF BACTERIAL ENDOTOXINS ON ANTIBODY FORMATION. VI. ENHANCEMENT OF ANTIBODY FORMATION BY NUCLEIC ACIDS.

Review 4. LACTIC DEHYDROGENASE VIRUS.

5. Human serum macroglobulins and dissociation units. I. Physicochemical properties.

6. Antigen elimination from the blood as an early manifestation of the immune response.

7. Sensitivity of passive haemagglutination for assay of 7S and 19S antibodies in primary rabbit anti-bovine serum albumin sera.

8. Maintenance of globulin levels in x-irradiated rabbits after immunization.

9. ULTRASTRUCTURE OF THE LACTIC DEHYDROGENASE VIRUS (LDV) AND CELL-VIRUS RELATIONSHIPS.

10. THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION.

1. Antibody-producing cells: virus-induced alteration of response to antigen.

2. Immune responses in mice infected with lactic dehydrogenase virus. I. Antibody response to DNP-BGG and hyperglobulinaemia in BALB/c mice.

3. Lymphocytic choriomeningitis of the mouse. IV. Depression of the allograft reaction.

4. Formation and biologic role of polyoma virus-antibody complexes. A critical role for complement.

5. Enzymatic and immunologic alterations in mice infected with lactic dehydrogenase virus.

6. Cytomegalovirus-induced immune suppression. I. Humoral immunity.

7. Passive haemagglutination for estimation of early and late anti-human gamma-globulin antibodies.

Review 8. Interactions of viruses with the immune system.

9. Immune reactivity of Visna virus-inoculated mice.

10. Divergence between immunosuppression and immunocompetence during virus-induced leukemogenesis.