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Literature DB >> 4964564

Enharncement of the hemolytic activity of the second component of human complement by oxidation.

Abstract

A method has been described for the chemical modification of human C'2 which results in a pronounced enhancement of its hemolytic activity and a marked increase in the stability of the intermediate complex EAC'1a,4,2a prepared with the modified C'2. Both effects are fully explained by the observed increase in activity and stability of the C'3 converting enzyme, C'4,2a, following its generation with modified C'2. Evidence has been presented in support of the hypothesis that the modification resulting from treatment of C'2 with a critical concentration of iodine consists of oxidation of one or more sulfhydryl group within the molecule.

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Year: 1967 PMID： 4964564 PMCID： PMC2138419 DOI： 10.1084/jem.126.6.1013

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

1. STUDIES ON HUMAN C'1-ESTERASE. I. PURIFICATION AND ENZYMATIC PROPERTIES.

Authors: A L HAINES; I H LEPOW
Journal: J Immunol Date: 1964-03 Impact factor: 5.422

Review 2. ACTIVE CENTER OF CARBOXYPEPTIDASE A.

Authors: B L VALLEE
Journal: Fed Proc Date: 1964 Jan-Feb

3. Carboxypeptidase A: approaches to the chemical nature of the active center and the mechanisms of action.

Authors: B L VALLEE; J F RIORDAN; J E COLEMAN
Journal: Proc Natl Acad Sci U S A Date: 1963-01-15 Impact factor: 11.205

4. The oxidation of protein thiol groups by iodate, bromate and persulphate.

Authors: F J HIRD; J R YATES
Journal: Biochem J Date: 1961-09 Impact factor: 3.857

5. Concerning the mechanism of complement action. V. The early steps in immune hemolysis.

Authors: E L BECKER
Journal: J Immunol Date: 1960-03 Impact factor: 5.422

6. The chemistry of iodination.

Authors: W L HUGHES
Journal: Ann N Y Acad Sci Date: 1957-08-30 Impact factor: 5.691

7. Kinetic studies on immune hemolysis. VII. Decay of EAC'1, 4, 2, fixation of C'3, and other factors influencing the hemolytic action of complement.

Authors: M M MAYER; L LEVINE; H J RAPP; A A MARUCCI
Journal: J Immunol Date: 1954-12 Impact factor: 5.422

8. Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement.

Authors: H J Müller-Eberhard; M J Polley; M A Calcott
Journal: J Exp Med Date: 1967-02-01 Impact factor: 14.307

9. ISOLATION OF BETA IF-GLOBULIN FROM HUMAN SERUM AND ITS CHARACTERIZATION AS THE FIFTH COMPONENT OF COMPLEMENT.

Authors: U R NILSSON; H J MUELLER-EBERHARD
Journal: J Exp Med Date: 1965-08-01 Impact factor: 14.307

10. ISOLATION AND DESCRIPTION OF THE FOURTH COMPONENT OF HUMAN COMPLEMENT.

Authors: H J MUELLER-EBERHARD; C E BIRO
Journal: J Exp Med Date: 1963-09-01 Impact factor: 14.307

71 in total

1. Chemotactic activity derived from interaction of factors D and B of the properdin pathway with cobra venom factor or C3B.

Authors: S Ruddy; K F Austen; E J Goetzl
Journal: J Clin Invest Date: 1975-03 Impact factor: 14.808

2. Complement bridges between cells analysis of a possible cell-cell interaction mechanism.

Authors: M P Dierich; B Landen
Journal: J Exp Med Date: 1977-12-01 Impact factor: 14.307

3. Hereditary deficiency of the fifth component of complement in man. I. Clinical, immunochemical, and family studies.

Authors: S I Rosenfeld; M E Kelly; J P Leddy
Journal: J Clin Invest Date: 1976-06 Impact factor: 14.808

4. Characterization of three monoclonal antibodies against C3 with selective specificities.

Authors: K Iida; K Mitomo; T Fujita; N Tamura
Journal: Immunology Date: 1987-11 Impact factor: 7.397

5. The reaction mechanism of human C5 in immune hemolysis.

Authors: N R Cooper; H J Müller-Eberhard
Journal: J Exp Med Date: 1970-10-01 Impact factor: 14.307

6. A case of deficiency of the seventh component of complement in man. Biological properties of a C7-deficient serum and description of a C7-inactivating principle.

Authors: B Wellek; W Opferkuch
Journal: Clin Exp Immunol Date: 1975-02 Impact factor: 4.330

7. Mechanism of resistance to complement-mediated killing of bacteria encoded by the Salmonella typhimurium virulence plasmid gene rck.

Authors: E J Heffernan; S Reed; J Hackett; J Fierer; C Roudier; D Guiney
Journal: J Clin Invest Date: 1992-09 Impact factor: 14.808

8. The effects of iodine and thiol-blocking reagents on complement component C2 and on the assembly of the classical-pathway C3 convertase.

Authors: M A Kerr; C Parkes
Journal: Biochem J Date: 1984-04-15 Impact factor: 3.857

9. The reaction of iodine and thiol-blocking reagents with human complement components C2 and factor B. Purification and N-terminal amino acid sequence of a peptide from C2a containing a free thiol group.

Authors: C Parkes; J Gagnon; M A Kerr
Journal: Biochem J Date: 1983-07-01 Impact factor: 3.857

10. Activation of the alternative complement pathway by exposure of phosphatidylethanolamine and phosphatidylserine on erythrocytes from sickle cell disease patients.

Authors: R H Wang; G Phillips; M E Medof; C Mold
Journal: J Clin Invest Date: 1993-09 Impact factor: 14.808