Literature DB >> 4270794

Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor.

E Dvornik, N Simard-Duquesne, M Krami, K Sestanj, K H Gabbay, J H Kinoshita, S D Varma, L O Merola.   

Abstract

An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose. When given orally, AY-22,284 markedly decreased the accumulation of polyols in the lenses and sciatic nerves of galactosemic rats and rats with streptozotocin-induced diabetes. In addition, treatment of galactosemic rats with AY-22,284 effectively suppressed the formation of cataracts.

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Year:  1973        PMID： 4270794     DOI： 10.1126/science.182.4117.1146

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  34 in total

Review 1.  The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.

Authors:  Oleg A Barski; Srinivas M Tipparaju; Aruni Bhatnagar
Journal:  Drug Metab Rev       Date:  2008       Impact factor: 4.518

2.  Inhibition of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary by alrestatin.

Authors:  W Lippmann
Journal:  Experientia       Date:  1978-04-15

3.  Studies on L-threose as substrate for aldose reductase: a possible role in preventing protein glycation.

Authors:  P S Devamanoharan; S D Varma
Journal:  Mol Cell Biochem       Date:  1996-06-21       Impact factor: 3.396

4.  Gene expression profiling of diabetic and galactosaemic cataractous rat lens by microarray analysis.

Authors:  E Kubo; D P Singh; Y Akagi
Journal:  Diabetologia       Date:  2005-03-11       Impact factor: 10.122

Review 5.  The effect of oxidants on biomembranes and cellular metabolism.

Authors:  S K Srivastava; N H Ansari; S Liu; A Izban; B Das; G Szabo; A Bhatnagar
Journal:  Mol Cell Biochem       Date:  1989 Nov 23-Dec 19       Impact factor: 3.396

6.  Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.

Authors:  A Y Lee; S K Chung; S S Chung
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

7.  Sorbitol metabolism in retina studied in vitro.

Authors:  P Naeser; S E Brolin; U J Eriksson
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1989       Impact factor: 3.117

8.  Red blood cell sorbitol dehydrogenase deficiency in a family with cataracts.

Authors:  G Vaca; B Ibarra; M Bracamontes; D García-Cruz; J Sánchez-Corona; C Medina; C Wunsch; G González-Quiroga; J M Cantú
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

9.  Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes.

Authors:  K P Palmano; P H Whiting; J N Hawthorne
Journal:  Biochem J       Date:  1977-10-01       Impact factor: 3.857

10.  Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.

Authors:  Vandana Sharma; Jonamani Nayak; Charles DeRossi; Adriana Charbono; Mie Ichikawa; Bobby G Ng; Erika Grajales-Esquivel; Anand Srivastava; Ling Wang; Ping He; David A Scott; Joseph Russell; Emily Contreras; Cherise M Guess; Stan Krajewski; Katia Del Rio-Tsonis; Hudson H Freeze
Journal:  FASEB J       Date:  2014-01-13       Impact factor: 5.191
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