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Literature DB >> 2721987

Sorbitol metabolism in retina studied in vitro.

Abstract

A new method is described which allows study of the retinal sorbitol metabolism in vitro. Bovine retinal tissue was incubated in tissue culture medium for 24 h and after this time showed only small morphological changes. The sorbitol content doubled at a glucose level of 5.5 mM compared with freshly prepared noncultured retina. Increasing glucose concentrations led to a gradual increase of the sorbitol content. Supplementation of the culture medium with fructose likewise enhanced the retinal sorbitol accumulation. An aldose reductase inhibitor (ICI 128436; Statil) significantly decreased the sorbitol content.

Entities: Chemical Gene Species

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Year: 1989 PMID： 2721987 DOI： 10.1007/BF02169793

Source DB: PubMed Journal: Graefes Arch Clin Exp Ophthalmol ISSN： 0721-832X Impact factor: 3.117

21 in total

Review 1. Mechanisms initiating cataract formation. Proctor Lecture.

Authors: J H Kinoshita
Journal: Invest Ophthalmol Date: 1974-10

Review 2. The sorbitol pathway and the complications of diabetes.

Authors: K H Gabbay
Journal: N Engl J Med Date: 1973-04-19 Impact factor: 91.245

3. Reversal, by treatment with an aldose reductase inhibitor, of impaired axonal transport and motor nerve conduction velocity in experimental diabetes mellitus.

Authors: D R Tomlinson; P R Holmes; J H Mayer
Journal: Neurosci Lett Date: 1982-08-16 Impact factor: 3.046

4. Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor.

Authors: W G Robison; P F Kador; J H Kinoshita
Journal: Science Date: 1983-09-16 Impact factor: 47.728

5. Galactose-induced retinal capillary basement membrane thickening: prevention by Sorbinil.

Authors: R N Frank; R J Keirn; A Kennedy; K W Frank
Journal: Invest Ophthalmol Vis Sci Date: 1983-11 Impact factor: 4.799

6. Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition.

Authors: K R Gillon; J N Hawthorne; D R Tomlinson
Journal: Diabetologia Date: 1983-10 Impact factor: 10.122

Sorbitol metabolism in retina studied in vitro.

Review 1. Mechanisms initiating cataract formation. Proctor Lecture.

Review 2. The sorbitol pathway and the complications of diabetes.

3. Reversal, by treatment with an aldose reductase inhibitor, of impaired axonal transport and motor nerve conduction velocity in experimental diabetes mellitus.

4. Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor.

5. Galactose-induced retinal capillary basement membrane thickening: prevention by Sorbinil.

6. Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition.

7. Altering the course of cataracts in diabetic rats.

8. The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats.

9. The sorbitol shunt in the retina and the optic nerve of mice with inherited and STZ-induced diabetes.

10. Prolonged fructose feeding and aldose reductase inhibition: effect on the polyol pathway in kidneys of normal rats.

1. The effects of an aldose reductase inhibitor on the progression of diabetic retinopathy.